A large variety of molecular interactions occurs between biomolecular components in cells. When a molecular interaction results in a regulatory effect, exerted by one component onto a downstream component, a so-called 'causal interaction' takes place. Causal interactions constitute the building blocks in our understanding of larger regulatory networks in cells. These causal interactions and the biological processes they enable (e.g., gene regulation) need to be described with a careful appreciation of the underlying molecular reactions. A proper description of this information enables archiving, sharing, and reuse by humans and for automated computational processing. Various representations of causal relationships between biological components are currently used in a variety of resources.

Touré, V., Vercruysse, S., Acencio, M.l., Lovering, R.c., Orchard, S., Bradley, G., et al. (2020). The minimum information about a molecular interaction CAusal STatement (MI2CAST). BIOINFORMATICS, 36(24), 5712-5718 [10.1093/bioinformatics/btaa622].

The minimum information about a molecular interaction CAusal STatement (MI2CAST)

Licata, Luana;Panni, Simona;Perfetto, Livia;
2020-01-01

Abstract

A large variety of molecular interactions occurs between biomolecular components in cells. When a molecular interaction results in a regulatory effect, exerted by one component onto a downstream component, a so-called 'causal interaction' takes place. Causal interactions constitute the building blocks in our understanding of larger regulatory networks in cells. These causal interactions and the biological processes they enable (e.g., gene regulation) need to be described with a careful appreciation of the underlying molecular reactions. A proper description of this information enables archiving, sharing, and reuse by humans and for automated computational processing. Various representations of causal relationships between biological components are currently used in a variety of resources.
2020
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/18 - GENETICA
English
https://academic.oup.com/bioinformatics/advance-article/doi/10.1093/bioinformatics/btaa622/5868560
Touré, V., Vercruysse, S., Acencio, M.l., Lovering, R.c., Orchard, S., Bradley, G., et al. (2020). The minimum information about a molecular interaction CAusal STatement (MI2CAST). BIOINFORMATICS, 36(24), 5712-5718 [10.1093/bioinformatics/btaa622].
Touré, V; Vercruysse, S; Acencio, Ml; Lovering, Rc; Orchard, S; Bradley, G; Casals-Casas, C; Chaouiya, C; Del-Toro, N; Flobak, A; Gaudet, P; Hermjako...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/255188
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