BackgroundEnvironmental pollution and weather changes unfavorably impact on cardiovascular disease. However, limited research has focused on ST-elevation myocardial infarction (STEMI), the most severe yet distinctive form of acute coronary syndrome.Methods and resultsWe appraised the impact of environmental and weather changes on the incidence of STEMI, analysing the bivariate and multivariable association between several environmental and atmospheric parameters and the daily incidence of STEMI in two large Italian urban areas. Specifically, we appraised: carbon monoxide (CO), nitrogen dioxide (NO2), nitric oxide (NOX), ozone, particulate matter smaller than 10 mu m (PM10) and than 2.5 mu m (PM2.5), temperature, atmospheric pressure, humidity and rainfall. A total of 4285 days at risk were appraised, with 3473 cases of STEMI. Specifically, no STEMI occurred in 1920 (44.8%) days, whereas one or more occurred in the remaining 2365 (55.2%) days. Multilevel modelling identified several pollution and weather predictors of STEMI. In particular, concentrations of CO (p=0.024), NOX (p=0.039), ozone (p=0.003), PM10 (p=0.033) and PM2.5 (p=0.042) predicted STEMI as early as three days before the event, as well as subsequently, and NO predicted STEMI one day before (p = 0.010), as well as on the same day. A similar predictive role was evident for temperature and atmospheric pressure (all p < 0.05).ConclusionsThe risk of STEMI is strongly associated with pollution and weather features. While causation cannot yet be proven, environmental and weather changes could be exploited to predict STEMI risk in the following days.

Biondi-Zoccai, G., Frati, G., Gaspardone, A., Mariano, E., Di Giosa, A.d., Bolignano, A., et al. (2020). Impact of environmental pollution and weather changes on the incidence of ST-elevation myocardial infarction. EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, 2, 1-8 [10.1177/2047487320928450].

Impact of environmental pollution and weather changes on the incidence of ST-elevation myocardial infarction

Gaspardone, Achille
Membro del Collaboration Group
;
Mariano, Enrica
Membro del Collaboration Group
;
Peruzzi, Mariangela
Membro del Collaboration Group
;
Federici, Massimo
Supervision
;
Romeo, Francesco
Membro del Collaboration Group
;
Versaci, Francesco
Writing – Original Draft Preparation
2020-06-02

Abstract

BackgroundEnvironmental pollution and weather changes unfavorably impact on cardiovascular disease. However, limited research has focused on ST-elevation myocardial infarction (STEMI), the most severe yet distinctive form of acute coronary syndrome.Methods and resultsWe appraised the impact of environmental and weather changes on the incidence of STEMI, analysing the bivariate and multivariable association between several environmental and atmospheric parameters and the daily incidence of STEMI in two large Italian urban areas. Specifically, we appraised: carbon monoxide (CO), nitrogen dioxide (NO2), nitric oxide (NOX), ozone, particulate matter smaller than 10 mu m (PM10) and than 2.5 mu m (PM2.5), temperature, atmospheric pressure, humidity and rainfall. A total of 4285 days at risk were appraised, with 3473 cases of STEMI. Specifically, no STEMI occurred in 1920 (44.8%) days, whereas one or more occurred in the remaining 2365 (55.2%) days. Multilevel modelling identified several pollution and weather predictors of STEMI. In particular, concentrations of CO (p=0.024), NOX (p=0.039), ozone (p=0.003), PM10 (p=0.033) and PM2.5 (p=0.042) predicted STEMI as early as three days before the event, as well as subsequently, and NO predicted STEMI one day before (p = 0.010), as well as on the same day. A similar predictive role was evident for temperature and atmospheric pressure (all p < 0.05).ConclusionsThe risk of STEMI is strongly associated with pollution and weather features. While causation cannot yet be proven, environmental and weather changes could be exploited to predict STEMI risk in the following days.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/06
English
Con Impact Factor ISI
Acute myocardial infarction
ST-elevation myocardial infarction
environment
pollution
weather
Biondi-Zoccai, G., Frati, G., Gaspardone, A., Mariano, E., Di Giosa, A.d., Bolignano, A., et al. (2020). Impact of environmental pollution and weather changes on the incidence of ST-elevation myocardial infarction. EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, 2, 1-8 [10.1177/2047487320928450].
Biondi-Zoccai, G; Frati, G; Gaspardone, A; Mariano, E; Di Giosa, Ad; Bolignano, A; Dei Giudici, A; Calcagno, S; Scappaticci, M; Sciarretta, S; Valenti, V; Casati, R; Visconti, G; Penco, M; Giannico, Mb; Peruzzi, M; Cavarretta, E; Budassi, S; Cosma, J; Federici, M; Roever, L; Romeo, F; Versaci, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/253133
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