The effectiveness of subgingival irrigant ozone-based as adjuvant for non-surgical periodontal therapy in the treatment of chronic periodontitis: A review.

The aim of this review was to establish the efficacy of Ozone therapy (OT) in Periodontal disease’s (PD) tratment. An electronic search of publications was established from two electronic databases: PubMed and Web of Science. The search strategy used a combination of controlled vocabulary and free-text words. Inclusion and exclusion criteria were defined by the authors before the start of the study. The inclusion criteria were: all studies published in English language; studies in vivo on humans; studies analyzing the correlation between PD and OT. The search resulted in 102 titles. Only 9 articles were included in the quantitative analysis. By the analyzed studies a strictly connection is still not evincible. More clinical trials are recommended to investigate the role of ozone, in its various types of topical administration, as a valid subgingival irrigant to achieve the goal of periodontal tissue health.