Glutathione (GSH) is the main non-enzymatic antioxidant playing an important role in detoxification, signal transduction by modulation of protein thiols redox status and direct scavenging of radicals. The latter function is not only performed against reactive oxygen species (ROS) but GSH also has a fundamental role in buffering nitric oxide (NO), a physiologically-produced molecule having-multifaceted functions. The efficient rate of GSH synthesis and high levels of GSH-dependent enzymes are characteristic features of healthy skeletal muscle where, besides the canonical functions, it is also involved in muscle contraction regulation. Moreover, NO production in skeletal muscle is a direct consequence of contractile activity and influences several metabolic myocyte pathways under both physiological and pathological conditions. In this review, we will consider the homeostasis and intersection of GSH with NO and then we will restrict the discussion on their role in processes related to skeletal muscle function and degeneration.

Baldelli, S., Ciccarone, F., Limongi, D., Checconi, P., Palamara, A.t., Ciriolo, M.r. (2019). Glutathione and Nitric Oxide: Key Team Players in Use and Disuse of Skeletal Muscle. NUTRIENTS, 11(10), 2318 [10.3390/nu11102318].

Glutathione and Nitric Oxide: Key Team Players in Use and Disuse of Skeletal Muscle

Ciccarone, Fabio;Ciriolo, Maria Rosa
2019-09-30

Abstract

Glutathione (GSH) is the main non-enzymatic antioxidant playing an important role in detoxification, signal transduction by modulation of protein thiols redox status and direct scavenging of radicals. The latter function is not only performed against reactive oxygen species (ROS) but GSH also has a fundamental role in buffering nitric oxide (NO), a physiologically-produced molecule having-multifaceted functions. The efficient rate of GSH synthesis and high levels of GSH-dependent enzymes are characteristic features of healthy skeletal muscle where, besides the canonical functions, it is also involved in muscle contraction regulation. Moreover, NO production in skeletal muscle is a direct consequence of contractile activity and influences several metabolic myocyte pathways under both physiological and pathological conditions. In this review, we will consider the homeostasis and intersection of GSH with NO and then we will restrict the discussion on their role in processes related to skeletal muscle function and degeneration.
30-set-2019
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/10 - BIOCHIMICA
English
atrophy
exercise
inflammation
nitrosative stress
oxidative stress
Animals
Glutathione
Homeostasis
Humans
Inflammation
Muscle, Skeletal
Muscular Atrophy
Nitric Oxide
Nitrosative Stress
Oxidative Stress
Signal Transduction
Energy Metabolism
Exercise
Muscle Contraction
Baldelli, S., Ciccarone, F., Limongi, D., Checconi, P., Palamara, A.t., Ciriolo, M.r. (2019). Glutathione and Nitric Oxide: Key Team Players in Use and Disuse of Skeletal Muscle. NUTRIENTS, 11(10), 2318 [10.3390/nu11102318].
Baldelli, S; Ciccarone, F; Limongi, D; Checconi, P; Palamara, At; Ciriolo, Mr
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/252793
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