There is evidence that mental health disorders may have roots in fetal life and are associated with defi-ciencies in various micronutrients, including vitamin D. During pregnancy, vitamin D balance is influenced by an increase in maternal calcitriol and a substantial increase in maternal Vitamin D Binding Protein concentrations. In the early stages of life, vitamin D is necessary to mediate numerous brain processes such as proliferation, apopto-sis, and neurotransmission. Furthermore, Vitamin D has a recognized anti-inflammatory activity that normally suppresses inflammation. Increased activation of hypothalamo-pituitary-adrenal axis (HPA) and inflammation during gestation may influence maternal health and fetal neurodevelopment during and beyond pregnancy. A deficit of Vitamin D and maternal stressful events during gestation, such as perinatal depression, could influence the efficacy of the immune system altering its activity. Vitamin D deficiency during gestation associated with a reduction in fetal brain development has been widely described and correlated with alteration in the production of the brain-derived neurotrophic factor. To this regard, many studies highlights that low maternal vitamin D dosage during gestation has been related to a significantly greater risk to develop schizophrenia and other severe mental illnesses in later life. The objective of this paper is a comprehensive overview of maternal vitamin D balance in determining the fetal origins of mental health with some references to the link between vitamin D levels, inflammatory responses to stress and mental disorders in adult life.
Lisi, G., Ribolsi, M., Siracusano, A., & Niolu, C. (2020). Maternal vitamin D and its role in determining fetal origins of mental health. CURRENT PHARMACEUTICAL DESIGN, 26(21), 2497-2509 [10.2174/1381612826666200506093858].
|Tipologia:||Articolo su rivista|
|Citazione:||Lisi, G., Ribolsi, M., Siracusano, A., & Niolu, C. (2020). Maternal vitamin D and its role in determining fetal origins of mental health. CURRENT PHARMACEUTICAL DESIGN, 26(21), 2497-2509 [10.2174/1381612826666200506093858].|
|Settore Scientifico Disciplinare:||Settore MED/25|
|Revisione (peer review):||Esperti anonimi|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.2174/1381612826666200506093858|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||2020|
|Titolo:||Maternal vitamin D and its role in determining fetal origins of mental health|
|Autori:||Lisi, G; Ribolsi, M; Siracusano, A; Niolu, C|
|Appare nelle tipologie:||01 - Articolo su rivista|