There is evidence that mental health disorders may have roots in fetal life and are associated with defi-ciencies in various micronutrients, including vitamin D. During pregnancy, vitamin D balance is influenced by an increase in maternal calcitriol and a substantial increase in maternal Vitamin D Binding Protein concentrations. In the early stages of life, vitamin D is necessary to mediate numerous brain processes such as proliferation, apopto-sis, and neurotransmission. Furthermore, Vitamin D has a recognized anti-inflammatory activity that normally suppresses inflammation. Increased activation of hypothalamo-pituitary-adrenal axis (HPA) and inflammation during gestation may influence maternal health and fetal neurodevelopment during and beyond pregnancy. A deficit of Vitamin D and maternal stressful events during gestation, such as perinatal depression, could influence the efficacy of the immune system altering its activity. Vitamin D deficiency during gestation associated with a reduction in fetal brain development has been widely described and correlated with alteration in the production of the brain-derived neurotrophic factor. To this regard, many studies highlights that low maternal vitamin D dosage during gestation has been related to a significantly greater risk to develop schizophrenia and other severe mental illnesses in later life. The objective of this paper is a comprehensive overview of maternal vitamin D balance in determining the fetal origins of mental health with some references to the link between vitamin D levels, inflammatory responses to stress and mental disorders in adult life.

Lisi, G., Ribolsi, M., Siracusano, A., Niolu, C. (2020). Maternal vitamin D and its role in determining fetal origins of mental health. CURRENT PHARMACEUTICAL DESIGN, 26(21), 2497-2509 [10.2174/1381612826666200506093858].

Maternal vitamin D and its role in determining fetal origins of mental health

Lisi G.;Ribolsi M.;Siracusano A.;Niolu C.
2020-01-01

Abstract

There is evidence that mental health disorders may have roots in fetal life and are associated with defi-ciencies in various micronutrients, including vitamin D. During pregnancy, vitamin D balance is influenced by an increase in maternal calcitriol and a substantial increase in maternal Vitamin D Binding Protein concentrations. In the early stages of life, vitamin D is necessary to mediate numerous brain processes such as proliferation, apopto-sis, and neurotransmission. Furthermore, Vitamin D has a recognized anti-inflammatory activity that normally suppresses inflammation. Increased activation of hypothalamo-pituitary-adrenal axis (HPA) and inflammation during gestation may influence maternal health and fetal neurodevelopment during and beyond pregnancy. A deficit of Vitamin D and maternal stressful events during gestation, such as perinatal depression, could influence the efficacy of the immune system altering its activity. Vitamin D deficiency during gestation associated with a reduction in fetal brain development has been widely described and correlated with alteration in the production of the brain-derived neurotrophic factor. To this regard, many studies highlights that low maternal vitamin D dosage during gestation has been related to a significantly greater risk to develop schizophrenia and other severe mental illnesses in later life. The objective of this paper is a comprehensive overview of maternal vitamin D balance in determining the fetal origins of mental health with some references to the link between vitamin D levels, inflammatory responses to stress and mental disorders in adult life.
2020
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/25 - PSICHIATRIA
English
Attention deficit hyperactivity disorder
Autism spectrum disorders
Maternal stress
Neurodevelopment
Perinatal depression
Pregnancy
Schizophrenia
Vitamin D
Lisi, G., Ribolsi, M., Siracusano, A., Niolu, C. (2020). Maternal vitamin D and its role in determining fetal origins of mental health. CURRENT PHARMACEUTICAL DESIGN, 26(21), 2497-2509 [10.2174/1381612826666200506093858].
Lisi, G; Ribolsi, M; Siracusano, A; Niolu, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/251650
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