Particle therapy uses protons or 12C beams for the treatment of deep-seated solid tumors. Due to the features of the energy deposition of charged particles in matter, a limited amount of dose is released to the healthy tissue in the beam entrance region, while the maximum of the dose is released to the tumor at the end of the beam range, in the Bragg peak region. However nuclear interactions between beam and patient tissues induce fragmentation both of projectile and target. This has to be carefully taken into account since different ions have different effectiveness in producing a biological damage. In 12C treatments the main concern are long range forward emitted secondary ions produced in projectile fragmentation that release dose in the healthy tissue after the tumor. Instead, in a proton treatment, the target fragmentation produces low energy, short range fragments along all the beam range. The FOOT experiment (FragmentatiOn Of Target) is designed to study these processes. Target nuclei (16O,12C) fragmentation induced by 150-250 MeV proton beam will be studied by means of the inverse kinematic approach. 16O,12C therapeutic beams, at the quoted kinetic energy per nucleon, collide on graphite and hydrocarbons target. The cross section on Hydrogen can be then extracted by subtraction. This configuration explores also the projectile fragmentation of these 16O,12C beams, or other ions of therapeutic interest, such as 4He for instance. The detector includes a magnetic spectrometer based on silicon pixel and strip detectors, a scintillating crystal calorimeter able to stop the heavier produced fragments, and a ∆E detector, with TOF capability, to achieve the needed energy resolution and particle identification. In addition to the electronic apparatus, an alternative setup based on the concept of the “Emulsion Cloud Chamber”, coupled with the interaction region of the electronic FOOT setup, will provide the measurement of lighter charged fragments: protons, deuterons, tritons and Helium nuclei. The FOOT data taking is foreseen in the available experimental rooms existing in the presently operational charged particle therapy facilities in Europe, and possibly at GSI. An initial phase with the emulsion setup will start in early 2018, while the complete electronic detector will take data starting in 2019. In this work a general description of the FOOT experiment and of its expected performances is presented.

Battistoni, G., Alexandrov, A., Argiro, S., Belcari, N., Biondi, S., Bisogni, M.g., et al. (2017). The FOOT (Fragmentation Of Target) Experiment. POS PROCEEDINGS OF SCIENCE, 302, 023 [10.22323/1.302.0023].

The FOOT (Fragmentation Of Target) Experiment

Morone, Maria Cristina;Narici, Livio;
2017-01-01

Abstract

Particle therapy uses protons or 12C beams for the treatment of deep-seated solid tumors. Due to the features of the energy deposition of charged particles in matter, a limited amount of dose is released to the healthy tissue in the beam entrance region, while the maximum of the dose is released to the tumor at the end of the beam range, in the Bragg peak region. However nuclear interactions between beam and patient tissues induce fragmentation both of projectile and target. This has to be carefully taken into account since different ions have different effectiveness in producing a biological damage. In 12C treatments the main concern are long range forward emitted secondary ions produced in projectile fragmentation that release dose in the healthy tissue after the tumor. Instead, in a proton treatment, the target fragmentation produces low energy, short range fragments along all the beam range. The FOOT experiment (FragmentatiOn Of Target) is designed to study these processes. Target nuclei (16O,12C) fragmentation induced by 150-250 MeV proton beam will be studied by means of the inverse kinematic approach. 16O,12C therapeutic beams, at the quoted kinetic energy per nucleon, collide on graphite and hydrocarbons target. The cross section on Hydrogen can be then extracted by subtraction. This configuration explores also the projectile fragmentation of these 16O,12C beams, or other ions of therapeutic interest, such as 4He for instance. The detector includes a magnetic spectrometer based on silicon pixel and strip detectors, a scintillating crystal calorimeter able to stop the heavier produced fragments, and a ∆E detector, with TOF capability, to achieve the needed energy resolution and particle identification. In addition to the electronic apparatus, an alternative setup based on the concept of the “Emulsion Cloud Chamber”, coupled with the interaction region of the electronic FOOT setup, will provide the measurement of lighter charged fragments: protons, deuterons, tritons and Helium nuclei. The FOOT data taking is foreseen in the available experimental rooms existing in the presently operational charged particle therapy facilities in Europe, and possibly at GSI. An initial phase with the emulsion setup will start in early 2018, while the complete electronic detector will take data starting in 2019. In this work a general description of the FOOT experiment and of its expected performances is presented.
2017
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore FIS/07 - FISICA APPLICATA (A BENI CULTURALI, AMBIENTALI, BIOLOGIA E MEDICINA)
English
Hadron therapy nuclear fragmentation
https://pos.sissa.it/302/023/
Battistoni, G., Alexandrov, A., Argiro, S., Belcari, N., Biondi, S., Bisogni, M.g., et al. (2017). The FOOT (Fragmentation Of Target) Experiment. POS PROCEEDINGS OF SCIENCE, 302, 023 [10.22323/1.302.0023].
Battistoni, G; Alexandrov, A; Argiro, S; Belcari, N; Biondi, S; Bisogni, Mg; Bruni, G; Brambilla, S; Camarlinghi, N; Cerello, P; Ciarrocchi, E; Clozza, A; De Lellis, G; Di Crescenzo, A; Durante, M; Faccini, R; Ferrero, V; Ferroni, F; Finck, C; Francesconi, M; Franchini, M; Galli, L; Garbini, M; Giraudo, G; Iarocci, E; Kanxheri, K; Lauria, A; La Tessa, C; Marafini, M; Mattei, I; Mirabelli, R; Montesi, Mc; Morone, Mc; Morrocchi, M; Muraro, S; Narici, L; Paramatti, R; Pastore, A; Pastrone, N; Patera, V; Peroni, C; Pullia, M; Ramello, L; Rosso, V; Rovituso, M; Sanelli, C; Sarti, A; Sartorelli, G; Sato, O; Schiavi, A; Schuy, C; Scifoni, E; Sciubba, A; Selvi, M; Servoli, L; Sitta, M; Spighi, R; Spiriti, E; Sportelli, G; Testa, M; Tioukov, V; Tommasino, F; Traini, G; Valle, Sm; Vanstalle, M; Villa, M; Weber, U; Zoccoli, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/250185
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