The concept of adaptive licensing (AL) has met with considerable interest. Yet some remain skeptical about its feasibility. Others argue that the focus and name of AL should be broadened. Against this background of ongoing debate, we examine the environmental changes that will likely make adaptive pathways the preferred approach in the future. The key drivers include: growing patient demand for timely access to promising therapies, emerging science leading to fragmentation of treatment populations, rising payer influence on product accessibility, and pressure on pharma/investors to ensure sustainability of drug development. We also discuss a number of environmental changes that will enable an adaptive paradigm. A life-span approach to bringing innovation to patients is expected to help address the perceived access vs. evidence trade-off, help de-risk drug development, and lead to better outcomes for patients.

Eichler, H.-., Baird, L.g., Barker, R., Bloechl-Daum, B., Borlum-Kristensen, F., Brown, J., et al. (2015). From adaptive licensing to adaptive pathways: Delivering a flexible life-span approach to bring new drugs to patients. CLINICAL PHARMACOLOGY & THERAPEUTICS, 97(3), 234-246 [10.1002/cpt.59].

From adaptive licensing to adaptive pathways: Delivering a flexible life-span approach to bring new drugs to patients

Lim R.;Rasi G.;
2015-01-01

Abstract

The concept of adaptive licensing (AL) has met with considerable interest. Yet some remain skeptical about its feasibility. Others argue that the focus and name of AL should be broadened. Against this background of ongoing debate, we examine the environmental changes that will likely make adaptive pathways the preferred approach in the future. The key drivers include: growing patient demand for timely access to promising therapies, emerging science leading to fragmentation of treatment populations, rising payer influence on product accessibility, and pressure on pharma/investors to ensure sustainability of drug development. We also discuss a number of environmental changes that will enable an adaptive paradigm. A life-span approach to bringing innovation to patients is expected to help address the perceived access vs. evidence trade-off, help de-risk drug development, and lead to better outcomes for patients.
2015
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
English
Eichler, H.-., Baird, L.g., Barker, R., Bloechl-Daum, B., Borlum-Kristensen, F., Brown, J., et al. (2015). From adaptive licensing to adaptive pathways: Delivering a flexible life-span approach to bring new drugs to patients. CLINICAL PHARMACOLOGY & THERAPEUTICS, 97(3), 234-246 [10.1002/cpt.59].
Eichler, H-; Baird, Lg; Barker, R; Bloechl-Daum, B; Borlum-Kristensen, F; Brown, J; Chua, R; Del Signore, S; Dugan, U; Ferguson, J; Garner, S; Goettsch, W; Haigh, J; Honig, P; Hoos, A; Huckle, P; Kondo, T; Le Cam, Y; Leufkens, H; Lim, R; Longson, C; Lumpkin, M; Maraganore, J; O'Rourke, B; Oye, K; Pezalla, E; Pignatti, F; Raine, J; Rasi, G; Salmonson, T; Samaha, D; Schneeweiss, S; Siviero, Pd; Skinner, M; Teagarden, Jr; Tominaga, T; Trusheim, Mr; Tunis, S; Unger, Tf; Vamvakas, S; Hirsch, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/247946
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