Benzazetidines and Related Compounds: Synthesis and Potential

Benzazetidines are a class of N -heterocycles potentially very interesting for a variety of purposes, including biological applications and drug design. In the past, their high ring strain has hampered the development of trustable, general and efficient synthetic methodologies for their preparation. In this review article we aim to disclose all the literature contributions about the synthesis of these compounds and the study of their reactivity, from the early examples to the most recent synthetic approaches. Recently, we noted a growth of interest for this heterocycle pushed by the publication of novel synthetic methodologies based on palladium catalyzed intramolecular C-H amination and organocatalyzed ring closure of 2-( N -Boc-anilino)- α -ketoesters/amides.