Artificial phosphodiesterases that combine a guanidinium unit with a general base connected by a m-xylylene linker catalyze the transesterification of the RNA model compound 2-hydroxypropyl p-nitrophenyl phosphate (HPNP). The bifunctional catalysts presented in this work show varying extents of cooperation between catalytic units and a rate enhancement of 4 x 10(4) in the most favorable case.
Salvio, R., Cacciapaglia, R., Mandolini, L. (2011). General base-guanidinium cooperation in bifunctional artificial phosphodiesterases. JOURNAL OF ORGANIC CHEMISTRY, 76(13), 5438-5443 [10.1021/jo2004007].
General base-guanidinium cooperation in bifunctional artificial phosphodiesterases
Salvio R.
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2011-01-01
Abstract
Artificial phosphodiesterases that combine a guanidinium unit with a general base connected by a m-xylylene linker catalyze the transesterification of the RNA model compound 2-hydroxypropyl p-nitrophenyl phosphate (HPNP). The bifunctional catalysts presented in this work show varying extents of cooperation between catalytic units and a rate enhancement of 4 x 10(4) in the most favorable case.File in questo prodotto:
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