Background: A Silastic ring has been used to prevent dilation of the gastrojejunostomy in Roux-en-Y gastric bypass (RYGBP), The use of a bio-membrane may prevent dilation of the anastomosis without the risks associated with prostheses. The aim of this study was to evaluate the feasibility and safety of applying such a bio-membrane around the gastrojejunostomy in Laparoscopic RYGBP (LRYGBP).Methods: We used a new bio-membrane, that is derived from porcine small intestinal submucosa (SIS) and acts as a scaffolding for the ingrowth of connective tissue. Over a 4-month period, 14 LRYGBP patients had their proximal anastomosis wrapped with 10 x 2.5 cm SIS by a single surgeon. We compared these patients to a control group of LRYGBP patients matched for BMI.Results: The average age of the patients was 35.0 years (control group: 45.1 years),The patients had a mean initial BMI of 44.7 kg/m(2) (+/-5.9) standard error, and the control subjects had a mean initial BMI of 46.7 kg/m(2) (+/-6.5). SIS application took a mean time of 11 (+/-3) minutes without any intraoperative complication. The median hospital stay was 3.5 days in the experimental group and 3.7 days in controls. Three patients developed a symptomatic stenosis at the gastrojejunostomy following surgery. In the control group there were two stenoses, At an average followup of 87 days (controls: 95 days), the mean reduction in BMI was 7.8 (+/-0.8) kg/m(2) [controls 8.6 kg/m(2) (+/-1.5)].Conclusion: Application of SIS around the gastrojejunostomy in patients undergoing LRYGBP is feasible and safe. Further follow-up is required, however, to evaluate the effectiveness in preventing dilation of the anastomosis.

Kini, S., Gagner, M., de Csepel, J., Gentileschi, P., Dakin, G. (2001). A biodegradeable membrane from porcine intestinal submucosa to reinforce the gastrojejunostomy in laparoscopic Roux-en-Y gastric bypass: Preliminary report. OBESITY SURGERY, 11(4), 469-473 [10.1381/096089201321209350].

A biodegradeable membrane from porcine intestinal submucosa to reinforce the gastrojejunostomy in laparoscopic Roux-en-Y gastric bypass: Preliminary report

Gentileschi P.;
2001

Abstract

Background: A Silastic ring has been used to prevent dilation of the gastrojejunostomy in Roux-en-Y gastric bypass (RYGBP), The use of a bio-membrane may prevent dilation of the anastomosis without the risks associated with prostheses. The aim of this study was to evaluate the feasibility and safety of applying such a bio-membrane around the gastrojejunostomy in Laparoscopic RYGBP (LRYGBP).Methods: We used a new bio-membrane, that is derived from porcine small intestinal submucosa (SIS) and acts as a scaffolding for the ingrowth of connective tissue. Over a 4-month period, 14 LRYGBP patients had their proximal anastomosis wrapped with 10 x 2.5 cm SIS by a single surgeon. We compared these patients to a control group of LRYGBP patients matched for BMI.Results: The average age of the patients was 35.0 years (control group: 45.1 years),The patients had a mean initial BMI of 44.7 kg/m(2) (+/-5.9) standard error, and the control subjects had a mean initial BMI of 46.7 kg/m(2) (+/-6.5). SIS application took a mean time of 11 (+/-3) minutes without any intraoperative complication. The median hospital stay was 3.5 days in the experimental group and 3.7 days in controls. Three patients developed a symptomatic stenosis at the gastrojejunostomy following surgery. In the control group there were two stenoses, At an average followup of 87 days (controls: 95 days), the mean reduction in BMI was 7.8 (+/-0.8) kg/m(2) [controls 8.6 kg/m(2) (+/-1.5)].Conclusion: Application of SIS around the gastrojejunostomy in patients undergoing LRYGBP is feasible and safe. Further follow-up is required, however, to evaluate the effectiveness in preventing dilation of the anastomosis.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/18
English
Con Impact Factor ISI
morbid obesity; Roux-en-Y gastric bypass; laparoscopy; small intestinal submucosa; gastrojejunostomy; Adult; Anastomosis, Roux-en-Y; Animals; Biodegradation, Environmental; Biological Dressings; Body Mass Index; Constriction, Pathologic; Feasibility Studies; Female; Follow-Up Studies; Gastric Bypass; Gastroscopy; Gastrostomy; Humans; Intestinal Mucosa; Jejunostomy; Length of Stay; Male; Middle Aged; Stomach; Swine; Treatment Outcome; Weight Loss; Wound Healing
Kini, S., Gagner, M., de Csepel, J., Gentileschi, P., Dakin, G. (2001). A biodegradeable membrane from porcine intestinal submucosa to reinforce the gastrojejunostomy in laparoscopic Roux-en-Y gastric bypass: Preliminary report. OBESITY SURGERY, 11(4), 469-473 [10.1381/096089201321209350].
Kini, S; Gagner, M; de Csepel, J; Gentileschi, P; Dakin, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/243334
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