In recent years, much research has been focused on the field of adoptive cell therapies (ACT) that use native or genetically modified T cells as therapeutic tools. Immunotherapy with T cells expressing chimeric antigen receptors (CARs) demonstrated great success in the treatment of haematologic malignancies, whereas adoptive transfer of autologous tumour infiltrating lymphocytes (TILs) proved to be highly effective in metastatic melanoma. These encouraging results initiated many studies where ACT was tested as a treatment for various solid tumours. In this review, we provide an overview of the challenges of T cell-based immunotherapies of solid tumours. We describe alternative approaches for choosing the most efficient T cells for cancer treatment in terms of their tumour-specificity and phenotype. Finally, we present strategies for improvement of anti-tumour potential of T cells, including combination therapies.

Chrusciel, E., Urban-Wojciuk, Z., Arcimowicz, L., Kurkowiak, M., Kowalski, J., Gliwinski, M., et al. (2020). Adoptive cell therapy—harnessing antigen-specific t cells to target solid tumours. CANCERS, 12(3), 683 [10.3390/cancers12030683].

Adoptive cell therapy—harnessing antigen-specific t cells to target solid tumours

Montesano C.;Bernardini R.;
2020-01-01

Abstract

In recent years, much research has been focused on the field of adoptive cell therapies (ACT) that use native or genetically modified T cells as therapeutic tools. Immunotherapy with T cells expressing chimeric antigen receptors (CARs) demonstrated great success in the treatment of haematologic malignancies, whereas adoptive transfer of autologous tumour infiltrating lymphocytes (TILs) proved to be highly effective in metastatic melanoma. These encouraging results initiated many studies where ACT was tested as a treatment for various solid tumours. In this review, we provide an overview of the challenges of T cell-based immunotherapies of solid tumours. We describe alternative approaches for choosing the most efficient T cells for cancer treatment in terms of their tumour-specificity and phenotype. Finally, we present strategies for improvement of anti-tumour potential of T cells, including combination therapies.
2020
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/04 - PATOLOGIA GENERALE
English
T cell-based therapy of solid tumours; TCR therapy; adoptive cell therapy of cancer; antigen- specific T cells; immunotherapy; neoantigens
Chrusciel, E., Urban-Wojciuk, Z., Arcimowicz, L., Kurkowiak, M., Kowalski, J., Gliwinski, M., et al. (2020). Adoptive cell therapy—harnessing antigen-specific t cells to target solid tumours. CANCERS, 12(3), 683 [10.3390/cancers12030683].
Chrusciel, E; Urban-Wojciuk, Z; Arcimowicz, L; Kurkowiak, M; Kowalski, J; Gliwinski, M; Marjanski, T; Rzyman, W; Biernat, W; Dziadziuszko, R; Montesano, C; Bernardini, R; Marek-Trzonkowska, N
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
2020 Chrusciel Cancers Review.pdf

accesso aperto

Licenza: Non specificato
Dimensione 8.87 MB
Formato Adobe PDF
8.87 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/239984
Citazioni
  • ???jsp.display-item.citation.pmc??? 13
  • Scopus 30
  • ???jsp.display-item.citation.isi??? 27
social impact