p73 is a transcription factor belonging to the p53 tumour suppressor family. p73(-/-) mice exhibit a range of phenotypes including neurological, reproductive and inflammatory defects. Although the role of p73 in the control of genomic stability explains part of these phenotypes, a clear mechanism of how p73 participates in the inflammatory response is still elusive. Interleukin-1 beta (IL-1 beta) has a crucial role in mediating the inflammatory response. Because of its high potency to induce inflammation, the activation and secretion of IL-1 beta is tightly regulated by large protein complexes, named inflammasomes. Inflammasomes regulate activation of proinflammatory caspase-1, which in turn proteolytically processes its substrates, including pro-IL-1 beta. Caspase-1 gene transcription is strongly activated by p53 protein family members including p73. Here, we have addressed whether p73 might be directly involved in IL-1 beta regulation and therefore in the control of the inflammatory response. Our results show that TAp73 beta upregulates pro-IL-1 beta mRNA and processed IL-1 beta protein. In addition, analysis of breast and lung cancer patient cohorts demonstrated that interaction between p73 and IL-1 beta predicts a negative survival outcome in these human cancers. (C) 2016 The Author(s). Published by Elsevier Inc.

Vikhreva, P., Petrova, V., Gokbulut, T., Pestlikis, I., Mancini, M., Di Daniele, N., et al. (2017). TAp73 upregulates IL-1 beta in cancer cells: Potential biornarker in lung and breast cancer?. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 482(3), 498-505 [10.1016/j.bbrc.2016.10.085].

TAp73 upregulates IL-1 beta in cancer cells: Potential biornarker in lung and breast cancer?

Petrova, Varvara;Pestlikis, Ilias;Mancini, Mara;Di Daniele, Nicola;Melino, Gennaro;Amelio, Ivano
2017-01-01

Abstract

p73 is a transcription factor belonging to the p53 tumour suppressor family. p73(-/-) mice exhibit a range of phenotypes including neurological, reproductive and inflammatory defects. Although the role of p73 in the control of genomic stability explains part of these phenotypes, a clear mechanism of how p73 participates in the inflammatory response is still elusive. Interleukin-1 beta (IL-1 beta) has a crucial role in mediating the inflammatory response. Because of its high potency to induce inflammation, the activation and secretion of IL-1 beta is tightly regulated by large protein complexes, named inflammasomes. Inflammasomes regulate activation of proinflammatory caspase-1, which in turn proteolytically processes its substrates, including pro-IL-1 beta. Caspase-1 gene transcription is strongly activated by p53 protein family members including p73. Here, we have addressed whether p73 might be directly involved in IL-1 beta regulation and therefore in the control of the inflammatory response. Our results show that TAp73 beta upregulates pro-IL-1 beta mRNA and processed IL-1 beta protein. In addition, analysis of breast and lung cancer patient cohorts demonstrated that interaction between p73 and IL-1 beta predicts a negative survival outcome in these human cancers. (C) 2016 The Author(s). Published by Elsevier Inc.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/10
English
Vikhreva, P., Petrova, V., Gokbulut, T., Pestlikis, I., Mancini, M., Di Daniele, N., et al. (2017). TAp73 upregulates IL-1 beta in cancer cells: Potential biornarker in lung and breast cancer?. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 482(3), 498-505 [10.1016/j.bbrc.2016.10.085].
Vikhreva, P; Petrova, V; Gokbulut, T; Pestlikis, I; Mancini, M; Di Daniele, N; Knight, Ra; Melino, G; Amelio, I
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/239148
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