p63 is a master regulator of epidermal biology, sustaining stemness and renewal capacity of the proliferating keratinocyte compartment. Hamanaka and Mutlu propose that p63 regulates the keratinocyte proliferation/differentiation switch by affecting the cellular glycolic rate through a direct transcriptional regulation of the metabolic enzyme PFKFB3. This finding sheds light on mechanisms underlining p63 function in the skin and suggests a role for energetic metabolism in epidermal biology.
Amelio, I., Melino, G., Candi, E. (2017). p63 Adjusts Sugar Taste of Epidermal Layers. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 137(6), 1204-1206 [10.1016/j.jid.2017.02.967].
p63 Adjusts Sugar Taste of Epidermal Layers
Amelio, Ivano
;Melino, Gennaro;Candi, Eleonora
2017-01-01
Abstract
p63 is a master regulator of epidermal biology, sustaining stemness and renewal capacity of the proliferating keratinocyte compartment. Hamanaka and Mutlu propose that p63 regulates the keratinocyte proliferation/differentiation switch by affecting the cellular glycolic rate through a direct transcriptional regulation of the metabolic enzyme PFKFB3. This finding sheds light on mechanisms underlining p63 function in the skin and suggests a role for energetic metabolism in epidermal biology.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
