Background: Surgical stress and anesthesia affect the patient's immune system. Analysis of the lymphocyte response after breast-conserving surgery was conducted to investigate the differences between effects after general and local anesthesia. Materials and Methods: Fifty-six patients with breast cancer were enrolled for BCS through local or general anesthesia. Total leukocytes, total lymphocytes, lymphocyte-subsets including CD3(+), CD19(+), CD4(+), CD8(+), CD16(+)CD56(+) and CD4(+)/CD8(+) ratio was examined at baseline and on postoperative days 1, 2 and 3. Results: Baseline data showed no statistical difference between the two groups. Within-group ANOVA test showed significant differences for total leukocyte count (p<0.001), total lymphocyte count (p=0.009) and proportion of natural-killer cells (p=0.01) in the control group. Between-group analysis showed lower median values of total lymphocytes in the awake surgery group on postoperative days 1, 2 and 3 (p=0.001, p=0.02 and p=0.01, respectively) when compared to the control group. Patients who underwent surgery under general anesthesia had higher total lymphocyte counts on postoperative day 2 (p=0.04). Conclusion: In this randomized study, breast-conserving surgery plus local anesthesia had a lower impact on postoperative lymphocyte response when compared to the same procedure performed under general anesthesia.
Vanni, G., Materazzo, M., Perretta, T., Meucci, R., Anemona, L., Buonomo, C., et al. (2019). Impact of awake breast cancer surgery on postoperative lymphocyte responses. IN VIVO, 33(6), 1879-1884.
|Tipologia:||Articolo su rivista|
|Citazione:||Vanni, G., Materazzo, M., Perretta, T., Meucci, R., Anemona, L., Buonomo, C., et al. (2019). Impact of awake breast cancer surgery on postoperative lymphocyte responses. IN VIVO, 33(6), 1879-1884.|
|Settore Scientifico Disciplinare:||Settore MED/18|
|Revisione (peer review):||Comitato scientifico|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.21873/invivo.11681|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||24-lug-2019|
|Titolo:||Impact of awake breast cancer surgery on postoperative lymphocyte responses|
|Autori:||Vanni, G; Materazzo, M; Perretta, T; Meucci, R; Anemona, L; Buonomo, C; Dauri, M; Granai, Av; Rho, M; Ingallinella, S; Tacconi, F; Ambrogi, V; Chiaravalloti, A; Schillaci, O; Petrella, G; Buonomo, Oc|
|Appare nelle tipologie:||01 - Articolo su rivista|