Background: Surgical stress and anesthesia affect the patient's immune system. Analysis of the lymphocyte response after breast-conserving surgery was conducted to investigate the differences between effects after general and local anesthesia. Materials and Methods: Fifty-six patients with breast cancer were enrolled for BCS through local or general anesthesia. Total leukocytes, total lymphocytes, lymphocyte-subsets including CD3(+), CD19(+), CD4(+), CD8(+), CD16(+)CD56(+) and CD4(+)/CD8(+) ratio was examined at baseline and on postoperative days 1, 2 and 3. Results: Baseline data showed no statistical difference between the two groups. Within-group ANOVA test showed significant differences for total leukocyte count (p<0.001), total lymphocyte count (p=0.009) and proportion of natural-killer cells (p=0.01) in the control group. Between-group analysis showed lower median values of total lymphocytes in the awake surgery group on postoperative days 1, 2 and 3 (p=0.001, p=0.02 and p=0.01, respectively) when compared to the control group. Patients who underwent surgery under general anesthesia had higher total lymphocyte counts on postoperative day 2 (p=0.04). Conclusion: In this randomized study, breast-conserving surgery plus local anesthesia had a lower impact on postoperative lymphocyte response when compared to the same procedure performed under general anesthesia.

Vanni, G., Materazzo, M., Perretta, T., Meucci, R., Anemona, L., Buonomo, C., et al. (2019). Impact of awake breast cancer surgery on postoperative lymphocyte responses. IN VIVO, 33(6), 1879-1884 [10.21873/invivo.11681].

Impact of awake breast cancer surgery on postoperative lymphocyte responses

Vanni, G;Perretta, T;Anemona, L;Dauri, M;Tacconi, F;Ambrogi, V;Chiaravalloti, A;Schillaci, O;Petrella, G;Buonomo, O. C
2019-07-24

Abstract

Background: Surgical stress and anesthesia affect the patient's immune system. Analysis of the lymphocyte response after breast-conserving surgery was conducted to investigate the differences between effects after general and local anesthesia. Materials and Methods: Fifty-six patients with breast cancer were enrolled for BCS through local or general anesthesia. Total leukocytes, total lymphocytes, lymphocyte-subsets including CD3(+), CD19(+), CD4(+), CD8(+), CD16(+)CD56(+) and CD4(+)/CD8(+) ratio was examined at baseline and on postoperative days 1, 2 and 3. Results: Baseline data showed no statistical difference between the two groups. Within-group ANOVA test showed significant differences for total leukocyte count (p<0.001), total lymphocyte count (p=0.009) and proportion of natural-killer cells (p=0.01) in the control group. Between-group analysis showed lower median values of total lymphocytes in the awake surgery group on postoperative days 1, 2 and 3 (p=0.001, p=0.02 and p=0.01, respectively) when compared to the control group. Patients who underwent surgery under general anesthesia had higher total lymphocyte counts on postoperative day 2 (p=0.04). Conclusion: In this randomized study, breast-conserving surgery plus local anesthesia had a lower impact on postoperative lymphocyte response when compared to the same procedure performed under general anesthesia.
24-lug-2019
Pubblicato
Rilevanza internazionale
Articolo
Comitato scientifico
Settore MED/18
English
Con Impact Factor ISI
Breast cancer; anaesthesia; awake surgery; cancer; conservative surgery; immune function; immunological; leukocytes; local anaesthesia; lymphocytes; surgery; white blood cell; Adult; Aged; Aged, 80 and over; Antigens, CD; Breast; Breast Neoplasms; Female; Humans; Leukocyte Count; Lymphocytes; Middle Aged; Postoperative Period; Prospective Studies; Wakefulness
Vanni, G., Materazzo, M., Perretta, T., Meucci, R., Anemona, L., Buonomo, C., et al. (2019). Impact of awake breast cancer surgery on postoperative lymphocyte responses. IN VIVO, 33(6), 1879-1884 [10.21873/invivo.11681].
Vanni, G; Materazzo, M; Perretta, T; Meucci, R; Anemona, L; Buonomo, C; Dauri, M; Granai, Av; Rho, M; Ingallinella, S; Tacconi, F; Ambrogi, V; Chiaravalloti, A; Schillaci, O; Petrella, G; Buonomo, Oc
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/238642
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