The main aim of this study was to investigate the possible association between F-18-choline uptake and histopathological features of prostate biopsies such as the Gleason Group and the expression of both epithelial to mesenchymal transition (vimentin) and bone mineralization (bone morphogenetics protein (BMP)-2, runt-related transcription factor 2 (RUNX2), receptor activator of nuclear factor-kappa B ligand (RANKL), vitamin D receptor (VDR), and pentraxin 3 (PTX3) in situ biomarkers. To this end, we enrolled 79 consecutive prostate cancer patients that underwent both the F-18-choline PET/CT analysis and the prostate bioptic procedure. The standardized uptake value (SUV) average values were collected from F-18-choline PET/CT analysis whereas Gleason Group and immunostaining data were collected from paraffin-embedded sections. Histological classification showed a heterogenous population including both low/intermediate and high-grade prostate cancers. A significant increase of F-18-choline uptake in high-grade prostate lesions (Gleason Score >= 8) was found. Also, linear regression analysis showed a significant correlation between F-18-choline uptake and the number of vimentin, RANKL, VDR, or PTX3 positive prostate cancer cells. Conversely, we observed no significant association between F-18-choline uptake and the expression of bone biomarkers involved in the early phases of osteoblast differentiation (BMP-2, RUNX2). In conclusion, results here reported can lay the foundation for the use of F-18-choline positron emission tomography (PET)/computed tomography (CT) as a diagnostic tool capable of identifying high-grade prostate cancer lesions expressing bone biomarkers.

Urbano, N., Scimeca, M., Crocco, A., Mauriello, A., Bonanno, E., Schillaci, O. (2019). 18F-Choline PET/CT Identifies High-Grade Prostate Cancer Lesions Expressing Bone Biomarkers. JOURNAL OF CLINICAL MEDICINE, 8(10), 1657 [10.3390/jcm8101657].

18F-Choline PET/CT Identifies High-Grade Prostate Cancer Lesions Expressing Bone Biomarkers

Scimeca, Manuel;Mauriello, Alessandro;Bonanno, Elena;Schillaci, Orazio
2019-10-11

Abstract

The main aim of this study was to investigate the possible association between F-18-choline uptake and histopathological features of prostate biopsies such as the Gleason Group and the expression of both epithelial to mesenchymal transition (vimentin) and bone mineralization (bone morphogenetics protein (BMP)-2, runt-related transcription factor 2 (RUNX2), receptor activator of nuclear factor-kappa B ligand (RANKL), vitamin D receptor (VDR), and pentraxin 3 (PTX3) in situ biomarkers. To this end, we enrolled 79 consecutive prostate cancer patients that underwent both the F-18-choline PET/CT analysis and the prostate bioptic procedure. The standardized uptake value (SUV) average values were collected from F-18-choline PET/CT analysis whereas Gleason Group and immunostaining data were collected from paraffin-embedded sections. Histological classification showed a heterogenous population including both low/intermediate and high-grade prostate cancers. A significant increase of F-18-choline uptake in high-grade prostate lesions (Gleason Score >= 8) was found. Also, linear regression analysis showed a significant correlation between F-18-choline uptake and the number of vimentin, RANKL, VDR, or PTX3 positive prostate cancer cells. Conversely, we observed no significant association between F-18-choline uptake and the expression of bone biomarkers involved in the early phases of osteoblast differentiation (BMP-2, RUNX2). In conclusion, results here reported can lay the foundation for the use of F-18-choline positron emission tomography (PET)/computed tomography (CT) as a diagnostic tool capable of identifying high-grade prostate cancer lesions expressing bone biomarkers.
11-ott-2019
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/08 - ANATOMIA PATOLOGICA
Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA
English
18F–choline; bone biomarkers; nuclear medicine; positron emission tomography; prostate cancer
Urbano, N., Scimeca, M., Crocco, A., Mauriello, A., Bonanno, E., Schillaci, O. (2019). 18F-Choline PET/CT Identifies High-Grade Prostate Cancer Lesions Expressing Bone Biomarkers. JOURNAL OF CLINICAL MEDICINE, 8(10), 1657 [10.3390/jcm8101657].
Urbano, N; Scimeca, M; Crocco, A; Mauriello, A; Bonanno, E; Schillaci, O
Articolo su rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/238492
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