In this paper, we investigate the effects of a point mutation on the enzymatic activity of copper-zinc superoxide dismutase, which we recently studied in detail by means of a theoretical-computational procedure (J Phys. Chem. B 2004, 108, 16255). Comparison of the reactivity of the initial catalytic steps in this mutant (G93A mutation far from the active site) with our previous data, reveals the beautiful mechanical-dynamical architecture of the enzyme, altered by such an apparently irrelevant mutation. Finally, our results suggest a possible atomic-molecular-based explanation for the mutant-pathology correlation, in line with the most recent experimental data.
Amadei, A., D'Alessandro, M., Paci, M., Di Nola, A., & Aschi, M. (2006). On the effect of a point mutation on the reactivity of CuZn superoxide dismutase: A theoretical study. JOURNAL OF PHYSICAL CHEMISTRY. B, CONDENSED MATTER, MATERIALS, SURFACES, INTERFACES & BIOPHYSICAL, 110(14), 7538-7544.
Tipologia: | Articolo su rivista |
Citazione: | Amadei, A., D'Alessandro, M., Paci, M., Di Nola, A., & Aschi, M. (2006). On the effect of a point mutation on the reactivity of CuZn superoxide dismutase: A theoretical study. JOURNAL OF PHYSICAL CHEMISTRY. B, CONDENSED MATTER, MATERIALS, SURFACES, INTERFACES & BIOPHYSICAL, 110(14), 7538-7544. |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore CHIM/02 - Chimica Fisica |
Revisione (peer review): | Sì, ma tipo non specificato |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1021/jp057095h |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | 2006 |
Titolo: | On the effect of a point mutation on the reactivity of CuZn superoxide dismutase: A theoretical study |
Autori: | |
Autori: | Amadei, A; D'Alessandro, M; Paci, M; Di Nola, A; Aschi, M |
Appare nelle tipologie: | 01 - Articolo su rivista |