Toll-like receptor 9 (TLR9), which recognizes hypomethylated DNA [cytosine-phosphate-guanine (CpG)], plays a role in the maintenance of serological memory and has been recently implicated in the pathogenesis of SLE. We previously reported that in vitro TLR9 triggers memory B-cell differentiation into antibody-producing cells, and that the MyD88-inhibitor ST2825 blocks TLR9-induced plasma cell (PC) generation. Here, we investigated whether memory B cells produce autoantibodies in SLE patients with active disease or in clinical remission, and whether ST2825 could inhibit PC generation in SLE patients.

Capolunghi, F., Rosado, M., Cascioli, S., Girolami, E., Bordasco, S., Vivarelli, M., et al. (2010). Pharmacological inhibition of TLR9 activation blocks autoantibody production in human B cells from SLE patients, 49(12), 2281-2289 [10.1093/rheumatology/keq226].

Pharmacological inhibition of TLR9 activation blocks autoantibody production in human B cells from SLE patients

SETTE, CLAUDIO;
2010-12-01

Abstract

Toll-like receptor 9 (TLR9), which recognizes hypomethylated DNA [cytosine-phosphate-guanine (CpG)], plays a role in the maintenance of serological memory and has been recently implicated in the pathogenesis of SLE. We previously reported that in vitro TLR9 triggers memory B-cell differentiation into antibody-producing cells, and that the MyD88-inhibitor ST2825 blocks TLR9-induced plasma cell (PC) generation. Here, we investigated whether memory B cells produce autoantibodies in SLE patients with active disease or in clinical remission, and whether ST2825 could inhibit PC generation in SLE patients.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/16
English
Con Impact Factor ISI
Capolunghi, F., Rosado, M., Cascioli, S., Girolami, E., Bordasco, S., Vivarelli, M., et al. (2010). Pharmacological inhibition of TLR9 activation blocks autoantibody production in human B cells from SLE patients, 49(12), 2281-2289 [10.1093/rheumatology/keq226].
Capolunghi, F; Rosado, M; Cascioli, S; Girolami, E; Bordasco, S; Vivarelli, M; Ruggiero, B; Cortis, E; Insalaco, A; Fantò, N; Gallo, G; Nucera, E; Loiarro, M; Sette, C; De Santis, R; Carsetti, R; Ruggiero, V
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/23596
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