Autophagy is a conserved self‐eating process that delivers cytoplasmic material to the lysosome to allow degradation of intracellular components, including soluble, unfolded and aggregated proteins, damaged organelles, and invading microorganisms. Autophagy provides a homeostatic control mechanism and is essential for balancing sources of energy in response to nutrient stress. Autophagic dysfunction or dysregulation has been implicated in several human pathologies, including cancer and neurodegeneration, and its modulation has substantial potential as a therapeutic strategy. Given the relevant clinical and therapeutic implications of autophagy, there is emerging intense interest in the identification of the key factors regulating the components of the autophagic machinery. Various post‐translational modifications, including ubiquitylation, have been implicated in autophagy control. The list of the E3 ubiquitin protein ligases involved in the regulation of several steps of the autophagic process is continuously growing. In this review, we will focus on recent advances in the understanding of the role of the homologous to the E6AP carboxyl terminus‐type E3 ubiquitin ligases in autophagy control.

Melino, G., Cecconi, F., Giuseppe Pelicci, P., Wah Mak, T., Bernassola, F. (2019). Emerging roles of HECT-type E3 ubiquitin ligases in autophagy regulation. MOLECULAR ONCOLOGY, 13, 2033-2048 [10.1002/1878-0261.12567].

Emerging roles of HECT-type E3 ubiquitin ligases in autophagy regulation.

Gerry Melino
Membro del Collaboration Group
;
Francesco Cecconi
Membro del Collaboration Group
;
Francesca Bernassola
Membro del Collaboration Group
2019-01-01

Abstract

Autophagy is a conserved self‐eating process that delivers cytoplasmic material to the lysosome to allow degradation of intracellular components, including soluble, unfolded and aggregated proteins, damaged organelles, and invading microorganisms. Autophagy provides a homeostatic control mechanism and is essential for balancing sources of energy in response to nutrient stress. Autophagic dysfunction or dysregulation has been implicated in several human pathologies, including cancer and neurodegeneration, and its modulation has substantial potential as a therapeutic strategy. Given the relevant clinical and therapeutic implications of autophagy, there is emerging intense interest in the identification of the key factors regulating the components of the autophagic machinery. Various post‐translational modifications, including ubiquitylation, have been implicated in autophagy control. The list of the E3 ubiquitin protein ligases involved in the regulation of several steps of the autophagic process is continuously growing. In this review, we will focus on recent advances in the understanding of the role of the homologous to the E6AP carboxyl terminus‐type E3 ubiquitin ligases in autophagy control.
2019
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/11 - BIOLOGIA MOLECOLARE
English
Con Impact Factor ISI
autophagy, HECT E3 ubiquitin ligases, proteasomal degradation, ubiquitylation
Melino, G., Cecconi, F., Giuseppe Pelicci, P., Wah Mak, T., Bernassola, F. (2019). Emerging roles of HECT-type E3 ubiquitin ligases in autophagy regulation. MOLECULAR ONCOLOGY, 13, 2033-2048 [10.1002/1878-0261.12567].
Melino, G; Cecconi, F; Giuseppe Pelicci, P; Wah Mak, T; Bernassola, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/235213
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