Four transglutaminase (TG) isoforms have been detected in epidermal keratinocytes: TG1, TG2, TG3, and TG5. Except for TG1 and TG3, their contribution to keratinocyte development and structure remains undefined. In this paper, we focused on the roles of TG2 and TG3 in imiquimod-induced psoriasis in mouse skin. We evaluated the severity of psoriasis markers in the skin of imiquimod-treated TG3 null and TG2 null mice. Our results showed that compromised TG3KO mouse skin was more responsive than WT or TG2KO mouse skin to the action of the pro-inflammatory drug imiquimod.
Piro, M.c., Ventura, A., Smirnov, A., Saggini, A., Lena, A.m., Mauriello, A., et al. (2020). Transglutaminase 3 reduces the severity of psoriasis in imiquimod‐treated mouse skin. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(5) [10.3390/ijms21051566].
Transglutaminase 3 reduces the severity of psoriasis in imiquimod‐treated mouse skin
Piro M. C.;Smirnov A.;Lena A. M.;Mauriello A.;Bianchi L.;Melino G.;Candi E.
2020-01-01
Abstract
Four transglutaminase (TG) isoforms have been detected in epidermal keratinocytes: TG1, TG2, TG3, and TG5. Except for TG1 and TG3, their contribution to keratinocyte development and structure remains undefined. In this paper, we focused on the roles of TG2 and TG3 in imiquimod-induced psoriasis in mouse skin. We evaluated the severity of psoriasis markers in the skin of imiquimod-treated TG3 null and TG2 null mice. Our results showed that compromised TG3KO mouse skin was more responsive than WT or TG2KO mouse skin to the action of the pro-inflammatory drug imiquimod.| File | Dimensione | Formato | |
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