Sympathetic nervous system activity is increased after cardiopulmonary arrest, resulting in vasoconstrictor release from the perivascular sympathetic nerves of cerebral arteries. However, the pathophysiological function of the perivascular sympathetic nerves in the ischemic brain remains unclear. A rat model of global cerebral ischemia (asphyxial cardiac arrest, ACA) was used to investigate perivascular sympathetic nerves of cerebral arteries via bilateral decentralization (preganglionic lesion) of the superior cervical ganglion (SCG). Decentralization of the SCG 5 days before ACA alleviated hypoperfusion and afforded hippocampal neuroprotection and improved functional outcomes. These studies can provide further insights into the functional mechanism(s) of the sympathetic nervous system during ischemia.

Lee, R.h., Couto e Silva, A., Lerner, F.m., Wilkins, C.s., Valido, S.e., Klein, D.d., et al. (2017). Interruption of perivascular sympathetic nerves of cerebral arteries offers neuroprotection against ischemia. AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY, 312(1), H182-H188 [10.1152/ajpheart.00482.2016].

Interruption of perivascular sympathetic nerves of cerebral arteries offers neuroprotection against ischemia

Della Morte D.;
2017-01-01

Abstract

Sympathetic nervous system activity is increased after cardiopulmonary arrest, resulting in vasoconstrictor release from the perivascular sympathetic nerves of cerebral arteries. However, the pathophysiological function of the perivascular sympathetic nerves in the ischemic brain remains unclear. A rat model of global cerebral ischemia (asphyxial cardiac arrest, ACA) was used to investigate perivascular sympathetic nerves of cerebral arteries via bilateral decentralization (preganglionic lesion) of the superior cervical ganglion (SCG). Decentralization of the SCG 5 days before ACA alleviated hypoperfusion and afforded hippocampal neuroprotection and improved functional outcomes. These studies can provide further insights into the functional mechanism(s) of the sympathetic nervous system during ischemia.
2017
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/09 - MEDICINA INTERNA
English
behavior (rodent); brain ischemia; cardiac arrest; cerebral blood flow; cerebral blood flow measurement; cognitive impairment; global ischemia; neuroprotection; pial vessels; sympathetic nervous system; two photon microscopy; Animals; Asphyxia; Brain; Brain Ischemia; CA1 Region, Hippocampal; Cell Death; Cerebral Arteries; Disease Models, Animal; Heart Arrest; Learning; Male; Memory; Microscopy, Confocal; Neurons; Neuroprotection; Rats; Rats, Sprague-Dawley; Neurovascular Coupling; Superior Cervical Ganglion; Sympathectomy; Sympathetic Nervous System
Lee, R.h., Couto e Silva, A., Lerner, F.m., Wilkins, C.s., Valido, S.e., Klein, D.d., et al. (2017). Interruption of perivascular sympathetic nerves of cerebral arteries offers neuroprotection against ischemia. AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY, 312(1), H182-H188 [10.1152/ajpheart.00482.2016].
Lee, Rh; Couto e Silva, A; Lerner, Fm; Wilkins, Cs; Valido, Se; Klein, Dd; Wu, Cy; Neumann, Jt; Della Morte, D; Koslow, Sh; Minagar, A; Lin, Hw
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/235021
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