Metformin is proposed as adjuvant therapy in cancer treatment because of its ability to limit cancer incidence by negatively modulating the PI3K/AKT/mTOR pathway. In vitro, in addition to inhibiting cancer cell proliferation, metformin can also induce apoptosis. The molecular mechanism underlying this second effect is still poorly characterized and published data are often contrasting. We investigated how nutrient availability can modulate metformin-induced apoptosis in three breast cancer cell lines.
Silvestri, A., Palumbo, F., Rasi, I., Posca, D., Pavlidou, T., Paoluzi, S., et al. (2015). Metformin induces apoptosis and downregulates pyruvate kinase M2 in breast cancer cells only when grown in nutrient-poor conditions. PLOS ONE, 10(8), e0136250 [10.1371/journal.pone.0136250].
Metformin induces apoptosis and downregulates pyruvate kinase M2 in breast cancer cells only when grown in nutrient-poor conditions
Rasi I.;Pavlidou T.;Paoluzi S.;Castagnoli L.
;Cesareni G.
2015-01-01
Abstract
Metformin is proposed as adjuvant therapy in cancer treatment because of its ability to limit cancer incidence by negatively modulating the PI3K/AKT/mTOR pathway. In vitro, in addition to inhibiting cancer cell proliferation, metformin can also induce apoptosis. The molecular mechanism underlying this second effect is still poorly characterized and published data are often contrasting. We investigated how nutrient availability can modulate metformin-induced apoptosis in three breast cancer cell lines.| File | Dimensione | Formato | |
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Metformin Induces Apoptosis and Downreg...When Grown in Nutrient-Poor Conditions.pdf
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