CancerGeneNet (https://signor.uniroma2.it/CancerGeneNet/) is a resource that links genes that are frequently mutated in cancers to cancer phenotypes. The resource takes advantage of a curation effort aimed at embedding a large fraction of the gene products that are found altered in cancer cells into a network of causal protein relationships. Graph algorithms, in turn, allow to infer likely paths of causal interactions linking cancer associated genes to cancer phenotypes thus offering a rational framework for the design of strategies to revert disease phenotypes. CancerGeneNet bridges two interaction layers by connecting proteins whose activities are affected by cancer drivers to proteins that impact on the 'hallmarks of cancer'. In addition, CancerGeneNet annotates curated pathways that are relevant to rationalize the pathological consequences of cancer driver mutations in selected common cancers and 'MiniPathways' illustrating regulatory circuits that are frequently altered in different cancers.

Iannuccelli, M., Micarelli, E., Surdo, P.l., Palma, A., Perfetto, L., Rozzo, I., et al. (2020). CancerGeneNet: linking driver genes to cancer hallmarks. NUCLEIC ACIDS RESEARCH, 48(D1), D416-D421 [10.1093/nar/gkz871].

CancerGeneNet: linking driver genes to cancer hallmarks

Iannuccelli, Marta;Micarelli, Elisa;Palma, Alessandro;Perfetto, Livia;Castagnoli, Luisa;Licata, Luana;Cesareni, Giovanni
2020-10-01

Abstract

CancerGeneNet (https://signor.uniroma2.it/CancerGeneNet/) is a resource that links genes that are frequently mutated in cancers to cancer phenotypes. The resource takes advantage of a curation effort aimed at embedding a large fraction of the gene products that are found altered in cancer cells into a network of causal protein relationships. Graph algorithms, in turn, allow to infer likely paths of causal interactions linking cancer associated genes to cancer phenotypes thus offering a rational framework for the design of strategies to revert disease phenotypes. CancerGeneNet bridges two interaction layers by connecting proteins whose activities are affected by cancer drivers to proteins that impact on the 'hallmarks of cancer'. In addition, CancerGeneNet annotates curated pathways that are relevant to rationalize the pathological consequences of cancer driver mutations in selected common cancers and 'MiniPathways' illustrating regulatory circuits that are frequently altered in different cancers.
ott-2020
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/18 - GENETICA
English
Con Impact Factor ISI
https://pubmed.ncbi.nlm.nih.gov/31598703
Iannuccelli, M., Micarelli, E., Surdo, P.l., Palma, A., Perfetto, L., Rozzo, I., et al. (2020). CancerGeneNet: linking driver genes to cancer hallmarks. NUCLEIC ACIDS RESEARCH, 48(D1), D416-D421 [10.1093/nar/gkz871].
Iannuccelli, M; Micarelli, E; Surdo, Pl; Palma, A; Perfetto, L; Rozzo, I; Castagnoli, L; Licata, L; Cesareni, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/234347
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