Herpes zoster (HZ; shingles)--a reactivation of the latent varicella zoster virus (VZV)--can cause significant morbidity. Its major complication is pain, particularly post-herpetic neuralgia (PHN). We will review the current management strategies available for the treatment of both acute HZ and PHN, including antiviral drugs, analgesic agents, anticonvulsants, tricyclic antidepressants and topical therapies. New molecules in development that show improved activity against VZV are also covered, and new drug targets are outlined. The role of translational neuroscience in moving towards a goal of finding disease-modifying treatments will be examined.

Whitley, R.J., Volpi, A., McKendrick, M., Wijck, A.v., & Oaklander, A.L. (2010). Management of herpes zoster and post-herpetic neuralgia now and in the future, 48 Suppl 1, S20-8 [10.1016/S1386-6532(10)70005-6].

Management of herpes zoster and post-herpetic neuralgia now and in the future

VOLPI, ANTONIO;
2010-05

Abstract

Herpes zoster (HZ; shingles)--a reactivation of the latent varicella zoster virus (VZV)--can cause significant morbidity. Its major complication is pain, particularly post-herpetic neuralgia (PHN). We will review the current management strategies available for the treatment of both acute HZ and PHN, including antiviral drugs, analgesic agents, anticonvulsants, tricyclic antidepressants and topical therapies. New molecules in development that show improved activity against VZV are also covered, and new drug targets are outlined. The role of translational neuroscience in moving towards a goal of finding disease-modifying treatments will be examined.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/17 - Malattie Infettive
English
Con Impact Factor ISI
Neuralgia, postherpetic; treatment outcome; antiviral agents; anticonvulsants; clinical trials as topic; antidepressive agents, tricyclic; analgesics; herpesvirus 3, human; herpes zoster; humans
Whitley, R.J., Volpi, A., McKendrick, M., Wijck, A.v., & Oaklander, A.L. (2010). Management of herpes zoster and post-herpetic neuralgia now and in the future, 48 Suppl 1, S20-8 [10.1016/S1386-6532(10)70005-6].
Whitley, R; Volpi, A; Mckendrick, M; Wijck, A; Oaklander, A
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/23380
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