Mesopontine tegmental nuclei such as the cuneiform, pedunculotegmental, oral pontine reticular, paramedian raphe and caudal linear raphe nuclei, are deep brain structures involved in arousal and motor function. Dysfunction of these nuclei is implicated in the pathogenesis of disorders of consciousness and sleep, as well as in neurodegenerative diseases. However, their localization in conventional neuroimages of living humans is difficult due to limited image sensitivity and contrast, and a stereotaxic probabilistic neuroimaging template of these nuclei in humans does not exist. We used semi-automatic segmentation of single-subject 1.1 mm-isotropic 7 T diffusion-fractional-anisotropy and T2-weighted images in healthy adults to generate an in vivo probabilistic neuroimaging structural template of these nuclei in standard stereotaxic (Montreal Neurological Institute, MNI) space. The template was validated through independent manual delineation, as well as leave-one-out validation and evaluation of nuclei volumes. This template can enable localization of five mesopontine tegmental nuclei in conventional images (e.g. 1.5 T, 3 T) in future studies of arousal and motor physiology (e.g. sleep, anesthesia, locomotion) and pathology (e.g. disorders of consciousness, sleep disorders, Parkinson's disease). The 7 T magnetic resonance imaging procedure for single-subject delineation of these nuclei may also prove useful for future 7 T studies of arousal and motor mechanisms.

Bianciardi, M., Strong, C., Toschi, N., Edlow, B.l., Fischl, B., Brown, E.n., et al. (2018). A probabilistic template of human mesopontine tegmental nuclei from in vivo 7 T MRI. NEUROIMAGE, 170, 222-230 [10.1016/j.neuroimage.2017.04.070].

A probabilistic template of human mesopontine tegmental nuclei from in vivo 7 T MRI

Toschi N.;
2018-01-01

Abstract

Mesopontine tegmental nuclei such as the cuneiform, pedunculotegmental, oral pontine reticular, paramedian raphe and caudal linear raphe nuclei, are deep brain structures involved in arousal and motor function. Dysfunction of these nuclei is implicated in the pathogenesis of disorders of consciousness and sleep, as well as in neurodegenerative diseases. However, their localization in conventional neuroimages of living humans is difficult due to limited image sensitivity and contrast, and a stereotaxic probabilistic neuroimaging template of these nuclei in humans does not exist. We used semi-automatic segmentation of single-subject 1.1 mm-isotropic 7 T diffusion-fractional-anisotropy and T2-weighted images in healthy adults to generate an in vivo probabilistic neuroimaging structural template of these nuclei in standard stereotaxic (Montreal Neurological Institute, MNI) space. The template was validated through independent manual delineation, as well as leave-one-out validation and evaluation of nuclei volumes. This template can enable localization of five mesopontine tegmental nuclei in conventional images (e.g. 1.5 T, 3 T) in future studies of arousal and motor physiology (e.g. sleep, anesthesia, locomotion) and pathology (e.g. disorders of consciousness, sleep disorders, Parkinson's disease). The 7 T magnetic resonance imaging procedure for single-subject delineation of these nuclei may also prove useful for future 7 T studies of arousal and motor mechanisms.
2018
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore FIS/07 - FISICA APPLICATA (A BENI CULTURALI, AMBIENTALI, BIOLOGIA E MEDICINA)
English
Ascending arousal and motor systems; Cuneiform/pedunculotegmental/oral pontine reticular/paramedian raphe/caudal linear raphe nuclei; Human mesopontine tegmental nuclei; In vivo neuroimaging template; Multi-contrast 7 T MRI
http://www.elsevier.com/inca/publications/store/6/2/2/9/2/5/index.htt
Bianciardi, M., Strong, C., Toschi, N., Edlow, B.l., Fischl, B., Brown, E.n., et al. (2018). A probabilistic template of human mesopontine tegmental nuclei from in vivo 7 T MRI. NEUROIMAGE, 170, 222-230 [10.1016/j.neuroimage.2017.04.070].
Bianciardi, M; Strong, C; Toschi, N; Edlow, Bl; Fischl, B; Brown, En; Rosen, Br; Wald, Ll
Articolo su rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/232540
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