Background and aim Cardiovascular diseases (CVDs) are the most frequent causes of death in the world. Inflammation and oxidative damage contribute significantly to the development of atherosclerosis and CVDs. European Food Safety Authority scientific opinion has acknowledged that hydroxytyrosol (3,4-dihydroxyphenylethanol) and derivatives, contained in extra virgin olive oil (EVOO), typically used in Mediterranean diet may play a crucial role in the reduction of the inflammatory pathway and in the prevention of CVDs. The aim of the study was to determine the effect in healthy volunteers of 25 g of phenols-rich EVOO (p-EVOO).Methods The clinical study was a randomized, controlled trial to determine the acute effect in the postprandial time of 25 g of p-EVOO. We evaluated nutritional status using anthropometric parameters, body composition, serum metabolites, oxidative stress biomarkers and gene expression of eight genes related to oxidative stress and human inflammasome pathways, lasting 2 h after p-EVOO administration. Twenty-two participants resulted as eligible for the study.Results A significant reduction of oxidized LDL, malondialdehyde, triglycerides and visceral adiposity index was highlighted (P < 0.05). Significant upregulation of catalase, superoxide dismutase 1 and upstream transcription factor 1 were observed (P < 0.05).Conclusion The current study shows that intake of 25 g of p-EVOO has been able to be modulated, in the postprandial time, the antioxidant profile and the expression of inflammation and oxidative stress-related genes, as superoxide dismutase 1, upstream transcription factor 1 and catalase. We also observed a significant reduction of oxidized LDL, malondialdehyde, triglycerides and visceral adiposity index. We have demonstrated that a daily intake of phenols and antioxidants can reduce the inflammatory pathway and oxidative stress and therefore the risk of atherosclerosis and CVDs. More studies on a larger population are necessary before definitive conclusions can be drawn.

Perrone, M.a., Gualtieri, P., Gratteri, S., Ali, W., Sergi, D., Muscoli, S., et al. (2019). Effects of postprandial hydroxytyrosol and derivates on oxidation of LDL, cardiometabolic state and gene expression: A nutrigenomic approach for cardiovascular prevention. JOURNAL OF CARDIOVASCULAR MEDICINE, 20(7), 419-426 [10.2459/JCM.0000000000000816].

Effects of postprandial hydroxytyrosol and derivates on oxidation of LDL, cardiometabolic state and gene expression: A nutrigenomic approach for cardiovascular prevention

Gualtieri P.;Ali W.;Sergi D.;Muscoli S.;Cammarano A.;Bernardini S.;Renzo L. D.;
2019-01-01

Abstract

Background and aim Cardiovascular diseases (CVDs) are the most frequent causes of death in the world. Inflammation and oxidative damage contribute significantly to the development of atherosclerosis and CVDs. European Food Safety Authority scientific opinion has acknowledged that hydroxytyrosol (3,4-dihydroxyphenylethanol) and derivatives, contained in extra virgin olive oil (EVOO), typically used in Mediterranean diet may play a crucial role in the reduction of the inflammatory pathway and in the prevention of CVDs. The aim of the study was to determine the effect in healthy volunteers of 25 g of phenols-rich EVOO (p-EVOO).Methods The clinical study was a randomized, controlled trial to determine the acute effect in the postprandial time of 25 g of p-EVOO. We evaluated nutritional status using anthropometric parameters, body composition, serum metabolites, oxidative stress biomarkers and gene expression of eight genes related to oxidative stress and human inflammasome pathways, lasting 2 h after p-EVOO administration. Twenty-two participants resulted as eligible for the study.Results A significant reduction of oxidized LDL, malondialdehyde, triglycerides and visceral adiposity index was highlighted (P < 0.05). Significant upregulation of catalase, superoxide dismutase 1 and upstream transcription factor 1 were observed (P < 0.05).Conclusion The current study shows that intake of 25 g of p-EVOO has been able to be modulated, in the postprandial time, the antioxidant profile and the expression of inflammation and oxidative stress-related genes, as superoxide dismutase 1, upstream transcription factor 1 and catalase. We also observed a significant reduction of oxidized LDL, malondialdehyde, triglycerides and visceral adiposity index. We have demonstrated that a daily intake of phenols and antioxidants can reduce the inflammatory pathway and oxidative stress and therefore the risk of atherosclerosis and CVDs. More studies on a larger population are necessary before definitive conclusions can be drawn.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/49
English
cardiovascular prevention; gene expression; hydroxytyrosol; oxidative stress; oxidation of LDL; Adolescent; Adult; Aged; Cardiovascular Diseases; Catalase; Diet, Healthy; Diet, Mediterranean; Double-Blind Method; Female; Humans; Inflammation Mediators; Lipoproteins, LDL; Male; Middle Aged; Nutrigenomics; Olive Oil; Oxidative Stress; Phenols; Phenylethyl Alcohol; Postprandial Period; Protective Factors; Risk Factors; Rome; Superoxide Dismutase-1; Upstream Stimulatory Factors; Young Adult
Perrone, M.a., Gualtieri, P., Gratteri, S., Ali, W., Sergi, D., Muscoli, S., et al. (2019). Effects of postprandial hydroxytyrosol and derivates on oxidation of LDL, cardiometabolic state and gene expression: A nutrigenomic approach for cardiovascular prevention. JOURNAL OF CARDIOVASCULAR MEDICINE, 20(7), 419-426 [10.2459/JCM.0000000000000816].
Perrone, Ma; Gualtieri, P; Gratteri, S; Ali, W; Sergi, D; Muscoli, S; Cammarano, A; Bernardini, S; Renzo, Ld; Romeo, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/232034
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