Apathy is the most common initial symptom of frontotemporal dementia (FTD) and has been linked to frontal-subcortical dopaminergic system dysfunction. No pharmacological therapy has been approved for the treatment of apathy, but, on the basis of its physiopathological mechanism, we suspected that increasing prefrontal dopaminergic innervation could improve this disabling symptom.

Callegari, I., Mattei, C., Benassi, F., Krueger, F., Grafman, J., Yaldizli, O., et al. (2016). Agomelatine improves apathy in frontotemporal dementia. NEURODEGENERATIVE DISEASES, 16(5-6), 352-356 [10.1159/000445873].

Agomelatine improves apathy in frontotemporal dementia

Emberti Gialloreti L.;
2016-01-01

Abstract

Apathy is the most common initial symptom of frontotemporal dementia (FTD) and has been linked to frontal-subcortical dopaminergic system dysfunction. No pharmacological therapy has been approved for the treatment of apathy, but, on the basis of its physiopathological mechanism, we suspected that increasing prefrontal dopaminergic innervation could improve this disabling symptom.
2016
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/01 - STATISTICA MEDICA
English
Acetamides; Antidepressive Agents; Apathy; Double-Blind Method; Female; Frontotemporal Dementia; Humans; Male; Melatonin; Middle Aged; Psychiatric Status Rating Scales; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Serotonin 5-HT2 Receptor Antagonists; Treatment Outcome
Callegari, I., Mattei, C., Benassi, F., Krueger, F., Grafman, J., Yaldizli, O., et al. (2016). Agomelatine improves apathy in frontotemporal dementia. NEURODEGENERATIVE DISEASES, 16(5-6), 352-356 [10.1159/000445873].
Callegari, I; Mattei, C; Benassi, F; Krueger, F; Grafman, J; Yaldizli, O; Sassos, D; Massucco, D; Scialo, C; Nobili, F; Serrati, C; Amore, M; Cocito, L; Emberti Gialloreti, L; Pardini, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/231950
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