BackgroundThe Mediterranean diet (MeD) plays a key role in the prevention of obesity. Among the genes involved in obesity, the Fat mass and obesity-associated gene (FTO) is one of the most known, but its interaction with MeD remained uncertain so far.MethodsWe carried out a study on a sample of 188 Italian subjects, analyzing their FTO rs9939609 alleles, and the difference in body composition between the baseline and a 4-weeks nutritional intervention. The sample was divided into two groups: the control group of 49 subjects, and the MeD group of 139 subjects.ResultsWe found significant relations between MeD and both variation of total body fat (TBFat) (p=0.00) and gynoid body fat (p=0.04). TBFat (kg) demonstrated to have a significant relation with the interaction diet-gene (p=0.04), whereas FTO was associated with the variation of total body water (p=0.02).ConclusionsMeD demonstrated to be a good nutritional treatment to reduce the body fat mass, whereas data about FTO remain uncertain. Confirming or rejecting the hypothesis of FTO and its influence on body tissues during nutritional treatments is fundamental to decide whether its effect has to be taken into consideration during both development of dietetic plans and patients monitoring.Trial Registration ClinicalTrials.gov Id: NCT01890070. Registered 01 July 2013, https://clinicaltrials.gov/ct2/show/NCT01890070

Di Renzo, L., Cioccoloni, G., Falco, S., Abenavoli, L., Moia, A., Sinibaldi Salimei, P., et al. (2018). Influence of FTO rs9939609 and Mediterranean diet on body composition and weight loss: A randomized clinical trial NCT01890070 NCT. JOURNAL OF TRANSLATIONAL MEDICINE, 16(1), 308 [10.1186/s12967-018-1680-7].

Influence of FTO rs9939609 and Mediterranean diet on body composition and weight loss: A randomized clinical trial NCT01890070 NCT

Di Renzo L.;Cioccoloni G.;Falco S.;Abenavoli L.;Moia A.;Sinibaldi Salimei P.;De Lorenzo A.
2018-01-01

Abstract

BackgroundThe Mediterranean diet (MeD) plays a key role in the prevention of obesity. Among the genes involved in obesity, the Fat mass and obesity-associated gene (FTO) is one of the most known, but its interaction with MeD remained uncertain so far.MethodsWe carried out a study on a sample of 188 Italian subjects, analyzing their FTO rs9939609 alleles, and the difference in body composition between the baseline and a 4-weeks nutritional intervention. The sample was divided into two groups: the control group of 49 subjects, and the MeD group of 139 subjects.ResultsWe found significant relations between MeD and both variation of total body fat (TBFat) (p=0.00) and gynoid body fat (p=0.04). TBFat (kg) demonstrated to have a significant relation with the interaction diet-gene (p=0.04), whereas FTO was associated with the variation of total body water (p=0.02).ConclusionsMeD demonstrated to be a good nutritional treatment to reduce the body fat mass, whereas data about FTO remain uncertain. Confirming or rejecting the hypothesis of FTO and its influence on body tissues during nutritional treatments is fundamental to decide whether its effect has to be taken into consideration during both development of dietetic plans and patients monitoring.Trial Registration ClinicalTrials.gov Id: NCT01890070. Registered 01 July 2013, https://clinicaltrials.gov/ct2/show/NCT01890070
2018
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/49 - SCIENZE TECNICHE DIETETICHE APPLICATE
English
Body composition; FTO; Mediterranean diet; Nutrigenetics; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Body Composition; Body Mass Index; Female; Gene Frequency; Humans; Italy; Male; Middle Aged; Polymorphism, Single Nucleotide; Weight Loss; Diet, Mediterranean
Di Renzo, L., Cioccoloni, G., Falco, S., Abenavoli, L., Moia, A., Sinibaldi Salimei, P., et al. (2018). Influence of FTO rs9939609 and Mediterranean diet on body composition and weight loss: A randomized clinical trial NCT01890070 NCT. JOURNAL OF TRANSLATIONAL MEDICINE, 16(1), 308 [10.1186/s12967-018-1680-7].
Di Renzo, L; Cioccoloni, G; Falco, S; Abenavoli, L; Moia, A; Sinibaldi Salimei, P; De Lorenzo, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/231879
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