Guided bone regeneration in patients taking biphosphonates: Two cases series

SUMMARY Bone tissue is a specialized form of connective tissue, characterized by the mineralization of the extracellular matrix which gives the fabric considerable hardness and strength. Bone is a dynamic tis-sue that is continually renewed and reshaped throughout life. The hypothesis is that the presence of heterologous bone in the graft reduces the possibility of post-operative bone resorption. There are different types of bone materials in dentistry. This study evaluates the different efficacy in patients receiving bisphosphonates. The radiographic examination allowed to highlight the presence of greater bone reabsorption in CASES A treated exclusively with autologous bone, compared to CASE B to which heterologous bone was also inserted. The literature is very poor, but the mix of the bone gives all the possible vantage of the two type of bone. Furthermore, the use of a membrane to cover the graft reduces the risk of reabsorption of this in the initial time and create greater stability. It is known, in fact, that the empty spaces between the graft and the recipient site can be colonized by connective tissue, which grows more rapidly than the bone.