Here we proposed the most recent innovations in the use of Breast Specific Gamma Imaging with 99mTc-sestamibi for the management of breast cancer patients. To this end, we reported the recent discoveries concerning: a) the implementation of both instrumental devices and software, b) the biological mechanisms involved in the 99mTc-sestamibi uptake in breast cancer cells, c) the evaluation of Breast Specific Gamma Imaging with 99mTc-sestamibi as predictive markers of metastatic diseases. In this last case, we also reported preliminary data about the capability of Breast Specific Gamma Imaging with 99mTc-sestamibi to identify breast cancer lesions with high propensity to form bone metastatic lesions due to the presence of Breast Osteoblast-Like Cells.

Urbano, N., Scimeca, M., Tancredi, V., Bonanno, E., Schillaci, O. (2022). 99mTC-sestamibi breast imaging: current status, new ideas and future perspectives, 84, 302-309 [10.1016/j.semcancer.2020.01.007].

99mTC-sestamibi breast imaging: current status, new ideas and future perspectives

Scimeca M.;Tancredi V.;Bonanno E.;Schillaci O.
2022-01-01

Abstract

Here we proposed the most recent innovations in the use of Breast Specific Gamma Imaging with 99mTc-sestamibi for the management of breast cancer patients. To this end, we reported the recent discoveries concerning: a) the implementation of both instrumental devices and software, b) the biological mechanisms involved in the 99mTc-sestamibi uptake in breast cancer cells, c) the evaluation of Breast Specific Gamma Imaging with 99mTc-sestamibi as predictive markers of metastatic diseases. In this last case, we also reported preliminary data about the capability of Breast Specific Gamma Imaging with 99mTc-sestamibi to identify breast cancer lesions with high propensity to form bone metastatic lesions due to the presence of Breast Osteoblast-Like Cells.
2022
Pubblicato
Rilevanza internazionale
Recensione
Esperti anonimi
Settore MED/08 - ANATOMIA PATOLOGICA
Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA
English
(99)mTC-sestamibi; Bone metastasis; Breast cancer; Dedicated breast gamma camera; Molecular imaging
Urbano, N., Scimeca, M., Tancredi, V., Bonanno, E., Schillaci, O. (2022). 99mTC-sestamibi breast imaging: current status, new ideas and future perspectives, 84, 302-309 [10.1016/j.semcancer.2020.01.007].
Urbano, N; Scimeca, M; Tancredi, V; Bonanno, E; Schillaci, O
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/231124
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