Critical limb ischemia (CLI) is considered the most severe pattern of peripheral artery disease. It is defined by the presence of chronic ischemic rest pain, ulceration or gangrene attributable to the occlusion of peripheral arterial vessels. It is associated with a high risk of major amputation, cardiovascular events and death. In this review, we presented a complete overview about physiopathology, diagnosis and holistic management of CLI. Revascularization is the first-line treatment, but several challenging cases are not treatable by conventional techniques. Unconventional techniques for the treatment of complex below-the-knee arterial disease are described. Furthermore, the state-of-the-art on gene and cell therapy for the treatment of no-option patients is reported.

Uccioli, L., Meloni, M., Izzo, V., Giurato, L., Merolla, S., Gandini, R. (2018). Critical limb ischemia: Current challenges and future prospects. VASCULAR HEALTH AND RISK MANAGEMENT, 14, 63-74 [10.2147/VHRM.S125065].

Critical limb ischemia: Current challenges and future prospects

Uccioli L.;Meloni M.;Giurato L.;Gandini R.
2018-01-01

Abstract

Critical limb ischemia (CLI) is considered the most severe pattern of peripheral artery disease. It is defined by the presence of chronic ischemic rest pain, ulceration or gangrene attributable to the occlusion of peripheral arterial vessels. It is associated with a high risk of major amputation, cardiovascular events and death. In this review, we presented a complete overview about physiopathology, diagnosis and holistic management of CLI. Revascularization is the first-line treatment, but several challenging cases are not treatable by conventional techniques. Unconventional techniques for the treatment of complex below-the-knee arterial disease are described. Furthermore, the state-of-the-art on gene and cell therapy for the treatment of no-option patients is reported.
2018
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/13 - ENDOCRINOLOGIA
English
cell therapy; critical limb ischemia; medical therapy; peripheral arterial disease; revascularization; Angiography; Clinical Decision-Making; Comorbidity; Critical Illness; Humans; Ischemia; Peripheral Arterial Disease; Predictive Value of Tests; Regional Blood Flow; Risk Factors; Treatment Outcome
Uccioli, L., Meloni, M., Izzo, V., Giurato, L., Merolla, S., Gandini, R. (2018). Critical limb ischemia: Current challenges and future prospects. VASCULAR HEALTH AND RISK MANAGEMENT, 14, 63-74 [10.2147/VHRM.S125065].
Uccioli, L; Meloni, M; Izzo, V; Giurato, L; Merolla, S; Gandini, R
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/228224
Citazioni
  • ???jsp.display-item.citation.pmc??? 35
  • Scopus 115
  • ???jsp.display-item.citation.isi??? 97
social impact