Skeletal muscle is characterized by an efficient regeneration potential that is often impaired during myopathies. Understanding the molecular players involved in muscle homeostasis and regeneration could help to find new therapies against muscle degenerative disorders. Previous studies revealed that the Ser/Thr kinase p21 protein-activated kinase 1 (Pak1) was specifically down-regulated in the atrophying gastrocnemius of Yoshida hepatoma-bearing rats. In this study, we evaluated the role of group I Paks during cancer-related atrophy and muscle regeneration.
Cerquone Perpetuini, A., Re Cecconi, A.d., Chiappa, M., Martinelli, G.b., Fuoco, C., Desiderio, G., et al. (2018). Group I Paks support muscle regeneration and counteract cancer-associated muscle atrophy. JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE, 9(4), 727-746-746 [10.1002/jcsm.12303].
Group I Paks support muscle regeneration and counteract cancer-associated muscle atrophy
Cerquone Perpetuini, AndreaMembro del Collaboration Group
;Fuoco, ClaudiaMembro del Collaboration Group
;Castagnoli, LuisaConceptualization
;Gargioli, CesareConceptualization
;Cesareni, GianniConceptualization
2018-08-01
Abstract
Skeletal muscle is characterized by an efficient regeneration potential that is often impaired during myopathies. Understanding the molecular players involved in muscle homeostasis and regeneration could help to find new therapies against muscle degenerative disorders. Previous studies revealed that the Ser/Thr kinase p21 protein-activated kinase 1 (Pak1) was specifically down-regulated in the atrophying gastrocnemius of Yoshida hepatoma-bearing rats. In this study, we evaluated the role of group I Paks during cancer-related atrophy and muscle regeneration.| File | Dimensione | Formato | |
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Group I Paks support muscle regeneratio...eract cancer-associated muscle atrophy.pdf
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