In recent years, a decrease in the incidence of tuberculosis (TB) has been recorded worldwide. However, an increase in TB cases has been reported in foreign people living in low-incidence countries, with an increase in extrapulmonary TB (EPTB) in the western region of the world. In the present work, a retrospective study was conducted in two Italian infectious diseases wards to evaluate the clinical characteristics of TB admission in the time period 2013-2017. A significant increase in TB was shown in the study period: 166 (71% males) patients with TB were enrolled, with ~70% coming from outside Italy (30% from Africa, 25% from Europe, and 13% from Asia and South America). Compared to foreign people, Italians were significantly older (71.5 (interquartile range, IQR: 44.5-80.0) vs. 30 (IQR: 24-40) years; p < 0.0001) more immunocompromised (48% vs. 17%; p < 0.0001), and affected by comorbidities (44% vs. 14%; p < 0.0001). EPTB represented 37% of all forms of the disease, and it was more incident in subjects coming from Africa than in those coming from Europe (39.3% vs. 20%, respectively). In logistic regression analysis, being European was protective (odd ratio, OR (95% CI): 0.2 (0.1-0.6); p = 0.004) against the development of EPTB forms. In conclusion, an increase in the rate of TB diagnosis was documented in two Italian reference centers in the period 2013-2017, with 39% of EPTB diagnosed in patients from outside Europe.

Campogiani, L., Compagno, M., Coppola, L., Malagnino, V., Maffongelli, G., Saraca, L.m., et al. (2019). Tuberculosis-related hospitalizations in a low-incidence country: A retrospective analysis in two Italian infectious diseases wards. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 17(1), 124 [10.3390/ijerph17010124].

Tuberculosis-related hospitalizations in a low-incidence country: A retrospective analysis in two Italian infectious diseases wards

Malagnino V.;Maffongelli G.;Grelli S.;Andreoni M.;Sarmati L.
2019-12-01

Abstract

In recent years, a decrease in the incidence of tuberculosis (TB) has been recorded worldwide. However, an increase in TB cases has been reported in foreign people living in low-incidence countries, with an increase in extrapulmonary TB (EPTB) in the western region of the world. In the present work, a retrospective study was conducted in two Italian infectious diseases wards to evaluate the clinical characteristics of TB admission in the time period 2013-2017. A significant increase in TB was shown in the study period: 166 (71% males) patients with TB were enrolled, with ~70% coming from outside Italy (30% from Africa, 25% from Europe, and 13% from Asia and South America). Compared to foreign people, Italians were significantly older (71.5 (interquartile range, IQR: 44.5-80.0) vs. 30 (IQR: 24-40) years; p < 0.0001) more immunocompromised (48% vs. 17%; p < 0.0001), and affected by comorbidities (44% vs. 14%; p < 0.0001). EPTB represented 37% of all forms of the disease, and it was more incident in subjects coming from Africa than in those coming from Europe (39.3% vs. 20%, respectively). In logistic regression analysis, being European was protective (odd ratio, OR (95% CI): 0.2 (0.1-0.6); p = 0.004) against the development of EPTB forms. In conclusion, an increase in the rate of TB diagnosis was documented in two Italian reference centers in the period 2013-2017, with 39% of EPTB diagnosed in patients from outside Europe.
dic-2019
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/17 - MALATTIE INFETTIVE
English
extrapulmonary tuberculosis; foreign people; pulmonary tuberculosis; tuberculosis
Campogiani, L., Compagno, M., Coppola, L., Malagnino, V., Maffongelli, G., Saraca, L.m., et al. (2019). Tuberculosis-related hospitalizations in a low-incidence country: A retrospective analysis in two Italian infectious diseases wards. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 17(1), 124 [10.3390/ijerph17010124].
Campogiani, L; Compagno, M; Coppola, L; Malagnino, V; Maffongelli, G; Saraca, Lm; Francisci, D; Baldelli, F; Fontana, C; Grelli, S; Andreoni, M; Sotgiu, G; Saderi, L; Sarmati, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/226949
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