Endocannabinoids are natural lipid molecules whose levels are regulated by specific biosynthetic and degradative enzymes. They bind to and activate two main cannabinoid receptors type 1 (CB1) and type 2 (CB2), and together with their metabolizing enzymes form the "endocannabinoid system" (ECS). In the last years, the relevance of endocannabinoids (eCBs) as critical modulators in various aspects of male reproduction has been pointed out. Mammalian male germ cells, from mitotic to haploid stage, have a complete ECS which is modulated during spermatogenesis. Compelling evidence indicate that in the testis an appropriate "eCBs tone", associated to a balanced CB receptors signaling, is critical for spermatogenesis and for the formation of mature and fertilizing spermatozoa. Any alteration of this system negatively affects male reproduction, from germ cell differentiation to sperm functions, and might have also an impact on testicular tumours. Indeed, most of testicular tumours develop during early germ-cell development in which a maturation arrest is thought to be the first key event leading to malignant transformation. Considering the ever-growing number and complexity of the data on ECS, this review focuses on the role of cannabinoid receptors CB1 and CB2 signaling in male germ cells development from gonocyte up to mature spermatozoa and in the induction of epigenetic alterations in these cells which might be transmitted to the progeny. Furthermore, we present new evidence on their relevance in testicular cancer.

Barchi, M., Innocenzi, E., Giannattasio, T., Dolci, S., Rossi, P., Grimaldi, P. (2019). Cannabinoid Receptors Signaling in the Development, Epigenetics, and Tumours of Male Germ Cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES [10.3390/ijms21010025].

Cannabinoid Receptors Signaling in the Development, Epigenetics, and Tumours of Male Germ Cells

Barchi, Marco
Conceptualization
;
Dolci, Susanna
Data Curation
;
Rossi, Pellegrino;Grimaldi, Paola
Conceptualization
2019-01-01

Abstract

Endocannabinoids are natural lipid molecules whose levels are regulated by specific biosynthetic and degradative enzymes. They bind to and activate two main cannabinoid receptors type 1 (CB1) and type 2 (CB2), and together with their metabolizing enzymes form the "endocannabinoid system" (ECS). In the last years, the relevance of endocannabinoids (eCBs) as critical modulators in various aspects of male reproduction has been pointed out. Mammalian male germ cells, from mitotic to haploid stage, have a complete ECS which is modulated during spermatogenesis. Compelling evidence indicate that in the testis an appropriate "eCBs tone", associated to a balanced CB receptors signaling, is critical for spermatogenesis and for the formation of mature and fertilizing spermatozoa. Any alteration of this system negatively affects male reproduction, from germ cell differentiation to sperm functions, and might have also an impact on testicular tumours. Indeed, most of testicular tumours develop during early germ-cell development in which a maturation arrest is thought to be the first key event leading to malignant transformation. Considering the ever-growing number and complexity of the data on ECS, this review focuses on the role of cannabinoid receptors CB1 and CB2 signaling in male germ cells development from gonocyte up to mature spermatozoa and in the induction of epigenetic alterations in these cells which might be transmitted to the progeny. Furthermore, we present new evidence on their relevance in testicular cancer.
Online ahead of print
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/16
English
cannabis; embryonal carcinoma; endocannabinoid system; epigenetic; intergenerational; male germ cells; sperm; spermatogenesis; testicular tumors
Barchi, M., Innocenzi, E., Giannattasio, T., Dolci, S., Rossi, P., Grimaldi, P. (2019). Cannabinoid Receptors Signaling in the Development, Epigenetics, and Tumours of Male Germ Cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES [10.3390/ijms21010025].
Barchi, M; Innocenzi, E; Giannattasio, T; Dolci, S; Rossi, P; Grimaldi, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/225711
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