Purpose of reviewRegardless of the underlying cause, skeletal muscle wasting is detrimental for a person's life quality, leading to impaired strength, locomotion, and physiological activity. Here, we propose a series of studies presenting tissue engineering-based approaches to reconstruct artificial muscle in vitro and in vivo.Recent findingsSkeletal muscle tissue engineering is attracting more and more attention from scientists, clinicians, patients, and media, thanks to the promising results obtained in the last decade with animal models of muscle wasting. The use of novel and refined biomimetic scaffolds mimicking three-dimensional muscle environment, thus supporting cell survival and differentiation, in combination with well characterized myogenic stem/progenitor cells, revealed the noteworthy potential of these technologies for creating artificial skeletal muscle tissue. In vitro, the production of three-dimensional muscle structures offer the possibility to generate a drug-screening platform for patient-specific pharmacological treatment, opening new frontiers in the development of new compounds with specific therapeutic actions. In vivo, three-dimensional artificial muscle biomimetic constructs offer the possibility to replace, in part or entirely, wasted muscle by means of straight reconstruction and/or by enhancing endogenous regeneration.SummaryReports of tissue engineering approaches for artificial muscle building appeared in large numbers in the specialized press lately, advocating the suitability of this technology for human application upon scaling up and a near future applicability for medical care of muscle wasting.Video abstracthttp://links.lww.com/COCN/A9

Fuoco, C., Cannata, S., Gargioli, C. (2016). Could a functional artificial skeletal muscle be useful in muscle wasting?. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 19(3), 182-187 [10.1097/MCO.0000000000000271].

Could a functional artificial skeletal muscle be useful in muscle wasting?

Fuoco C.;Cannata S.;Gargioli C.
2016-05-19

Abstract

Purpose of reviewRegardless of the underlying cause, skeletal muscle wasting is detrimental for a person's life quality, leading to impaired strength, locomotion, and physiological activity. Here, we propose a series of studies presenting tissue engineering-based approaches to reconstruct artificial muscle in vitro and in vivo.Recent findingsSkeletal muscle tissue engineering is attracting more and more attention from scientists, clinicians, patients, and media, thanks to the promising results obtained in the last decade with animal models of muscle wasting. The use of novel and refined biomimetic scaffolds mimicking three-dimensional muscle environment, thus supporting cell survival and differentiation, in combination with well characterized myogenic stem/progenitor cells, revealed the noteworthy potential of these technologies for creating artificial skeletal muscle tissue. In vitro, the production of three-dimensional muscle structures offer the possibility to generate a drug-screening platform for patient-specific pharmacological treatment, opening new frontiers in the development of new compounds with specific therapeutic actions. In vivo, three-dimensional artificial muscle biomimetic constructs offer the possibility to replace, in part or entirely, wasted muscle by means of straight reconstruction and/or by enhancing endogenous regeneration.SummaryReports of tissue engineering approaches for artificial muscle building appeared in large numbers in the specialized press lately, advocating the suitability of this technology for human application upon scaling up and a near future applicability for medical care of muscle wasting.Video abstracthttp://links.lww.com/COCN/A9
19-mag-2016
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/13 - BIOLOGIA APPLICATA
English
Con Impact Factor ISI
biomaterial scaffold; muscle tissue wasting; myogenic stem; progenitor cells; skeletal muscle tissue engineering; Animals; Guided Tissue Regeneration; Humans; Tissue Engineering; Wasting Syndrome; Muscle, Skeletal
Fuoco, C., Cannata, S., Gargioli, C. (2016). Could a functional artificial skeletal muscle be useful in muscle wasting?. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 19(3), 182-187 [10.1097/MCO.0000000000000271].
Fuoco, C; Cannata, S; Gargioli, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/225124
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