An Enterobacter ludwigii strain was isolated during routine screening of a Japanese patient for carriage of carbapenem-resistant Enterobacteriaceae. PCR analysis revealed the blaNMC-A carbapenemase gene. Whole-genome sequencing revealed that blaNMC-A was inserted in the chromosome and associated with a novel 29.1-kb putative Xer-dependent integrative mobile element, named EludIMEX-1. Bioinformatic analysis identified similar elements in the genomes of an Enterobacter asburiae strain and of other Enterobacter cloacae complex strains, confirming the mobile nature of this element.
Antonelli, A., D'Andrea, M.m., Di Pilato, V., Viaggi, B., Torricelli, F., Rossolini, G.m. (2015). Characterization of a novel putative Xer-dependent integrative mobile element carrying the blaNMC-A carbapenemase gene, inserted into the chromosome of members of the Enterobacter cloacae complex. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 59(10), 6620-6624 [10.1128/AAC.01452-15].
Characterization of a novel putative Xer-dependent integrative mobile element carrying the blaNMC-A carbapenemase gene, inserted into the chromosome of members of the Enterobacter cloacae complex
D'Andrea M. M.;
2015-01-01
Abstract
An Enterobacter ludwigii strain was isolated during routine screening of a Japanese patient for carriage of carbapenem-resistant Enterobacteriaceae. PCR analysis revealed the blaNMC-A carbapenemase gene. Whole-genome sequencing revealed that blaNMC-A was inserted in the chromosome and associated with a novel 29.1-kb putative Xer-dependent integrative mobile element, named EludIMEX-1. Bioinformatic analysis identified similar elements in the genomes of an Enterobacter asburiae strain and of other Enterobacter cloacae complex strains, confirming the mobile nature of this element.| File | Dimensione | Formato | |
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