Obesity and low-grade inflammation are associated with an increased risk of hepatocellular carcinoma (HCC), a leading cause of cancer-related death worldwide. The tissue inhibitor of metalloproteinase (TIMP) 3, an endogenous inhibitor of protease activity that represents a key mediator of inflammation, is reduced in inflammatory metabolic disorders and cancer. In contrast, Timp3-deficient mice (Timp3-/-) are highly resistant to developing HCC in response to a diethylnitrosamine (DEN); therefore, we aimed to elucidate the biological role of genetic loss of Timp3 in obesity-related hepatocarcinogenesis.

Casagrande, V., Mauriello, A., Anemona, L., Mavilio, M., Iuliani, G., De Angelis, L., et al. (2019). Timp3 deficiency affects the progression of DEN-related hepatocellular carcinoma during diet-induced obesity in mice. ACTA DIABETOLOGICA, 56(12), 1265-1274 [10.1007/s00592-019-01382-x].

Timp3 deficiency affects the progression of DEN-related hepatocellular carcinoma during diet-induced obesity in mice

Casagrande V.;Mauriello A.;Anemona L.;Mavilio M.;Iuliani G.;De Angelis L.;Federici M.;Menghini R.
2019-01-01

Abstract

Obesity and low-grade inflammation are associated with an increased risk of hepatocellular carcinoma (HCC), a leading cause of cancer-related death worldwide. The tissue inhibitor of metalloproteinase (TIMP) 3, an endogenous inhibitor of protease activity that represents a key mediator of inflammation, is reduced in inflammatory metabolic disorders and cancer. In contrast, Timp3-deficient mice (Timp3-/-) are highly resistant to developing HCC in response to a diethylnitrosamine (DEN); therefore, we aimed to elucidate the biological role of genetic loss of Timp3 in obesity-related hepatocarcinogenesis.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/09 - Medicina Interna
Settore MED/08
English
Hepatocellular carcinoma; Inflammation; Obesity; TIMP3
Casagrande, V., Mauriello, A., Anemona, L., Mavilio, M., Iuliani, G., De Angelis, L., et al. (2019). Timp3 deficiency affects the progression of DEN-related hepatocellular carcinoma during diet-induced obesity in mice. ACTA DIABETOLOGICA, 56(12), 1265-1274 [10.1007/s00592-019-01382-x].
Casagrande, V; Mauriello, A; Anemona, L; Mavilio, M; Iuliani, G; De Angelis, L; D'Onofrio, M; Arisi, I; Federici, M; Menghini, R
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/221965
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