The skin is a peripheral lymphoid organ, being the first immunological defense against infections as the initial interface between the organism and the external background. The maintenance of the skin immune homeostasis depends on a finely equilibrium of well-regulated relations between different cells and exogenous pathogens. Inflammatory skin diseases are directly linked to the dysregulation of this equilibrium. The present review discusses the role of the immune system, of T cells, in the etiopathogenesis of psoriasis, illustrating a potential rationale for innovative therapeutic intervention.

Lanna, C., Mancini, M., Gaziano, R., Cannizzaro, M.v., Galluzzo, M., Talamonti, M., et al. (2019). Skin immunity and its dysregulation in psoriasis. CELL CYCLE, 18(20), 2581-2589 [10.1080/15384101.2019.1653099].

Skin immunity and its dysregulation in psoriasis

Gaziano R.;Galluzzo M.;Talamonti M.;Rovella V.;Melino G.;Campione E.;Bianchi L.
2019-01-01

Abstract

The skin is a peripheral lymphoid organ, being the first immunological defense against infections as the initial interface between the organism and the external background. The maintenance of the skin immune homeostasis depends on a finely equilibrium of well-regulated relations between different cells and exogenous pathogens. Inflammatory skin diseases are directly linked to the dysregulation of this equilibrium. The present review discusses the role of the immune system, of T cells, in the etiopathogenesis of psoriasis, illustrating a potential rationale for innovative therapeutic intervention.
2019
Pubblicato
Rilevanza internazionale
Recensione
Nessuno
Settore MED/35 - MALATTIE CUTANEE E VENEREE
English
Psoriasis; biologic therapies; cytokines; immunity; lymphocytes
Lanna, C., Mancini, M., Gaziano, R., Cannizzaro, M.v., Galluzzo, M., Talamonti, M., et al. (2019). Skin immunity and its dysregulation in psoriasis. CELL CYCLE, 18(20), 2581-2589 [10.1080/15384101.2019.1653099].
Lanna, C; Mancini, M; Gaziano, R; Cannizzaro, Mv; Galluzzo, M; Talamonti, M; Rovella, V; Annicchiarico-Petruzzelli, M; Melino, G; Wang, Y; Shi, Y; Campione, E; Bianchi, L
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
Skin immunity and its dysregulation in psoriasis.pdf

solo utenti autorizzati

Licenza: Copyright dell'editore
Dimensione 3.46 MB
Formato Adobe PDF
3.46 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/221605
Citazioni
  • ???jsp.display-item.citation.pmc??? 5
  • Scopus 21
  • ???jsp.display-item.citation.isi??? 19
social impact