Background: Recent studies suggest that transmitted drug resistance (TDR) may be decreasing in latest years, likely because of the reduced frequency of acquired resistance. However, specific risk factors, geographical areas and special HIV-infected populations may be disproportionally affected by TDR.Objectives: Correlates of TDR and time trends were evaluated from 2007 to 2014.Study design: We evaluated the genotypic results of 2155 naive patients enrolled in the I.Co.N.A cohort at 23 clinical Centers in Italy between 2007 and 2014. A weighted analysis was performed to account for the patients enrolled in the cohort in each clinical Centre at each biennium (total number of patients: 3737).Results: Overall prevalence of TDR was 10.7%. Independent predictors of TDR were sexual risk factor (OR 2.315, p = 0.020) and non-Italian geographical origin (OR 1.57, p = 0.038). The weighted prevalence of TDR was 10.5% with a stable proportion over calendar years. Generally, TDR prevalence was numerically higher, although not significantly, in clinical Centers of metropolitan areas with more than 3 millions of residents as compared to others (11.3% vs. 9.2%). The difference in TDR prevalence between these Centers decreased in more recent years.Conclusions: A stable frequency of TDR was observed during the most recent years in Italy, with opposite and converging trends in large metropolitan areas as compared to the rest of the country, suggesting a more homogeneous spread of TDR across the country in latest years. Concerns remain for sexual route of infection and non-Italian origin, reinforcing the need for specific prevention strategies prioritizing specific populations.

Franzetti, M., De Luca, A., Ceccherini-Silberstein, F., Spagnuolo, V., Nicastri, E., Mussini, C., et al. (2018). Evolution of HIV-1 transmitted drug resistance in Italy in the 2007–2014 period: A weighted analysis. JOURNAL OF CLINICAL VIROLOGY, 106, 49-52 [10.1016/j.jcv.2018.07.009].

Evolution of HIV-1 transmitted drug resistance in Italy in the 2007–2014 period: A weighted analysis

De Luca A.;Ceccherini-Silberstein F.;
2018-01-01

Abstract

Background: Recent studies suggest that transmitted drug resistance (TDR) may be decreasing in latest years, likely because of the reduced frequency of acquired resistance. However, specific risk factors, geographical areas and special HIV-infected populations may be disproportionally affected by TDR.Objectives: Correlates of TDR and time trends were evaluated from 2007 to 2014.Study design: We evaluated the genotypic results of 2155 naive patients enrolled in the I.Co.N.A cohort at 23 clinical Centers in Italy between 2007 and 2014. A weighted analysis was performed to account for the patients enrolled in the cohort in each clinical Centre at each biennium (total number of patients: 3737).Results: Overall prevalence of TDR was 10.7%. Independent predictors of TDR were sexual risk factor (OR 2.315, p = 0.020) and non-Italian geographical origin (OR 1.57, p = 0.038). The weighted prevalence of TDR was 10.5% with a stable proportion over calendar years. Generally, TDR prevalence was numerically higher, although not significantly, in clinical Centers of metropolitan areas with more than 3 millions of residents as compared to others (11.3% vs. 9.2%). The difference in TDR prevalence between these Centers decreased in more recent years.Conclusions: A stable frequency of TDR was observed during the most recent years in Italy, with opposite and converging trends in large metropolitan areas as compared to the rest of the country, suggesting a more homogeneous spread of TDR across the country in latest years. Concerns remain for sexual route of infection and non-Italian origin, reinforcing the need for specific prevention strategies prioritizing specific populations.
2018
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
English
Antiretroviral resistance; HIV infection; Transmitted resistance; Weighted analysis; Adult; Anti-HIV Agents; Drug Resistance, Viral; Female; HIV Infections; HIV Seropositivity; HIV-1; Humans; Longitudinal Studies; Male; Middle Aged; Prevalence; Retrospective Studies; Risk Factors; Spatio-Temporal Analysis; Time Factors; Young Adult; Genotype
Franzetti, M., De Luca, A., Ceccherini-Silberstein, F., Spagnuolo, V., Nicastri, E., Mussini, C., et al. (2018). Evolution of HIV-1 transmitted drug resistance in Italy in the 2007–2014 period: A weighted analysis. JOURNAL OF CLINICAL VIROLOGY, 106, 49-52 [10.1016/j.jcv.2018.07.009].
Franzetti, M; De Luca, A; Ceccherini-Silberstein, F; Spagnuolo, V; Nicastri, E; Mussini, C; Antinori, A; Monno, L; Vecchiet, J; Fanti, I; d'Arminio Mo...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/219577
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