The inhibitory effect of the flavonoid naringenin on plant and human Two-Pore Channels (TPCs) was assessed by means of electrophysiological measurements. By acting on human TPC2, naringenin, was able to dampen intracellular calcium responses to VEGF in cultured human endothelial cells and to impair angiogenic activity in VEGF-containing matrigel plugs implanted in mice. Molecular docking predicts selective binding sites for naringenin in the TPC structure, thus suggesting a specific interaction between the flavonoid and the channel.

Benkerrou, D., Minicozzi, V., Gradogna, A., Milenkovic, S., Bodrenko, I.v., Festa, M., et al. (2019). A perspective on the modulation of plant and animal two pore channels (TPCs) by the flavonoid naringenin. BIOPHYSICAL CHEMISTRY, 254, 106246 [10.1016/j.bpc.2019.106246].

A perspective on the modulation of plant and animal two pore channels (TPCs) by the flavonoid naringenin

Minicozzi V.;
2019-08-01

Abstract

The inhibitory effect of the flavonoid naringenin on plant and human Two-Pore Channels (TPCs) was assessed by means of electrophysiological measurements. By acting on human TPC2, naringenin, was able to dampen intracellular calcium responses to VEGF in cultured human endothelial cells and to impair angiogenic activity in VEGF-containing matrigel plugs implanted in mice. Molecular docking predicts selective binding sites for naringenin in the TPC structure, thus suggesting a specific interaction between the flavonoid and the channel.
ago-2019
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore FIS/07 - FISICA APPLICATA (A BENI CULTURALI, AMBIENTALI, BIOLOGIA E MEDICINA)
English
Animal lysosome; Fluorescence; Molecular docking; Patch-clamp; Plant vacuole; TPC channels
Benkerrou, D., Minicozzi, V., Gradogna, A., Milenkovic, S., Bodrenko, I.v., Festa, M., et al. (2019). A perspective on the modulation of plant and animal two pore channels (TPCs) by the flavonoid naringenin. BIOPHYSICAL CHEMISTRY, 254, 106246 [10.1016/j.bpc.2019.106246].
Benkerrou, D; Minicozzi, V; Gradogna, A; Milenkovic, S; Bodrenko, Iv; Festa, M; Lagostena, L; Cornara, L; D'Amore, A; Ceccarelli, M; Filippini, A; Car...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/218983
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