Bilateral peduncolopontine nucleus (PPN) and subthalamic nucleus (STN) deep brain stimulation (DBS) was performed in six-advanced Parkinson's disease (PD) patients. We report the effect of both PPN-DBS (25 Hz) and STN-DBS (185 Hz) on patient spinal reflex excitability by utilizing the soleus-Hoffman reflex (HR) threshold. Compared to controls (n = 9), patients showed an increase of HR-threshold, which was scarcely affected by levodopa, but significantly reduced by DBS. In particular, we found that PPN-DBS alone, or plus STN-DBS induced a complete recovery of HR-threshold up to control values. The HR-threshold changes, although do not allow to investigate the contribution of specific intraspinal pathways, suggest that PPN may play a key-role in modulating spinal excitability in PD possibly by improving the basal ganglia-brainstem descending system activity.

Stefani, A. (2008). Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson's disease patients. JOURNAL OF NEURAL TRANSMISSION, 115(5), 731-735 [10.1007/s00702-007-0001-8].

Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson's disease patients

STEFANI A
2008-05-01

Abstract

Bilateral peduncolopontine nucleus (PPN) and subthalamic nucleus (STN) deep brain stimulation (DBS) was performed in six-advanced Parkinson's disease (PD) patients. We report the effect of both PPN-DBS (25 Hz) and STN-DBS (185 Hz) on patient spinal reflex excitability by utilizing the soleus-Hoffman reflex (HR) threshold. Compared to controls (n = 9), patients showed an increase of HR-threshold, which was scarcely affected by levodopa, but significantly reduced by DBS. In particular, we found that PPN-DBS alone, or plus STN-DBS induced a complete recovery of HR-threshold up to control values. The HR-threshold changes, although do not allow to investigate the contribution of specific intraspinal pathways, suggest that PPN may play a key-role in modulating spinal excitability in PD possibly by improving the basal ganglia-brainstem descending system activity.
mag-2008
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/26 - NEUROLOGIA
English
H-Reflex; Spinal Cord; Parkinson Disease; Deep Brain Stimulation; Humans; Case-Control Studies; Aged; Middle Aged; Dose-Response Relationship, Radiation; Pedunculopontine Tegmental Nucleus; Male; Female
Stefani, A. (2008). Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson's disease patients. JOURNAL OF NEURAL TRANSMISSION, 115(5), 731-735 [10.1007/s00702-007-0001-8].
Stefani, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/218382
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