Extracorporeal shock wave therapy (ESWT) is a non-invasive and innovative technology for the management of specific tendinopathies. In order to elucidate the ESWT-mediated clinical benefits, human Tendon-derived Stem/Progenitor cells (hTSPCs) explanted from 5 healthy semitendinosus (ST) and 5 ruptured Achilles (AT) tendons were established. While hTSPCs from the two groups showed similar proliferation rates and stem cell surface marker profiles, we found that the clonogenic potential was maintained only in cells derived from healthy donors. Interestingly, ESWT significantly accelerated hTSPCs differentiation, suggesting that the clinical benefits of ESWT may be ascribed to increased efficiency of tendon repair after injury.

Leone, L., Raffa, S., Vetrano, M., Ranieri, D., Malisan, F., Scrofani, C., et al. (2016). Extracorporeal Shock Wave Treatment (ESWT) enhances the in vitro-induced differentiation of human tendon-derived stem/progenitor cells (hTSPCs). ONCOTARGET, 7(6), 6410-6423 [10.18632/oncotarget.7064].

Extracorporeal Shock Wave Treatment (ESWT) enhances the in vitro-induced differentiation of human tendon-derived stem/progenitor cells (hTSPCs)

Malisan F.;
2016-01-01

Abstract

Extracorporeal shock wave therapy (ESWT) is a non-invasive and innovative technology for the management of specific tendinopathies. In order to elucidate the ESWT-mediated clinical benefits, human Tendon-derived Stem/Progenitor cells (hTSPCs) explanted from 5 healthy semitendinosus (ST) and 5 ruptured Achilles (AT) tendons were established. While hTSPCs from the two groups showed similar proliferation rates and stem cell surface marker profiles, we found that the clonogenic potential was maintained only in cells derived from healthy donors. Interestingly, ESWT significantly accelerated hTSPCs differentiation, suggesting that the clinical benefits of ESWT may be ascribed to increased efficiency of tendon repair after injury.
2016
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/04 - PATOLOGIA GENERALE
English
ESWT; Pathology Section; differentiation; healing; stem cells; tendon; Adipogenesis; Cell Differentiation; Cell Proliferation; Cells, Cultured; Fluorescent Antibody Technique; Humans; In Vitro Techniques; Osteogenesis; Stem Cells; Tendon Injuries; Tendons; High-Energy Shock Waves
Leone, L., Raffa, S., Vetrano, M., Ranieri, D., Malisan, F., Scrofani, C., et al. (2016). Extracorporeal Shock Wave Treatment (ESWT) enhances the in vitro-induced differentiation of human tendon-derived stem/progenitor cells (hTSPCs). ONCOTARGET, 7(6), 6410-6423 [10.18632/oncotarget.7064].
Leone, L; Raffa, S; Vetrano, M; Ranieri, D; Malisan, F; Scrofani, C; Vulpiani, Mc; Ferretti, A; Torrisi, Mr; Visco, V
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/215357
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