Tuberous sclerosis complex (TSC) is associated with a wide range of behavioral, psychiatric, intellectual, academic, neuropsychological, and psychosocial difficulties, which are often underdiagnosed and undertreated. Here, we present a clinical update on TSC-associated neuropsychiatric disorders, abbreviated as TAND, to guide screening, diagnosis, and treatment in practice. The review is aimed at clinical geneticists, genetic counselors, pediatricians, and all generalists involved in the assessment and treatment of children, adolescents and adults with TSC, and related disorders. The review starts with a summary of the construct and levels of TAND, before presenting up-to-date information about each level of investigation. The review concludes with a synopsis of current and future TAND research.

de Vries, P.j., Wilde, L., de Vries, M.c., Moavero, R., Pearson, D.a., Curatolo, P. (2018). A clinical update on tuberous sclerosis complex-associated neuropsychiatric disorders (TAND). AMERICAN JOURNAL OF MEDICAL GENETICS. PART C, SEMINARS IN MEDICAL GENETICS, 178(3), 309-320 [10.1002/ajmg.c.31637].

A clinical update on tuberous sclerosis complex-associated neuropsychiatric disorders (TAND)

Moavero R.;Curatolo P.
2018-01-01

Abstract

Tuberous sclerosis complex (TSC) is associated with a wide range of behavioral, psychiatric, intellectual, academic, neuropsychological, and psychosocial difficulties, which are often underdiagnosed and undertreated. Here, we present a clinical update on TSC-associated neuropsychiatric disorders, abbreviated as TAND, to guide screening, diagnosis, and treatment in practice. The review is aimed at clinical geneticists, genetic counselors, pediatricians, and all generalists involved in the assessment and treatment of children, adolescents and adults with TSC, and related disorders. The review starts with a summary of the construct and levels of TAND, before presenting up-to-date information about each level of investigation. The review concludes with a synopsis of current and future TAND research.
2018
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/39 - NEUROPSICHIATRIA INFANTILE
English
ADHD; TANDTSC; anxiety; autism spectrum disorder; behavior; depression; mental health; neuropsychological deficits; scholastic difficulties
de Vries, P.j., Wilde, L., de Vries, M.c., Moavero, R., Pearson, D.a., Curatolo, P. (2018). A clinical update on tuberous sclerosis complex-associated neuropsychiatric disorders (TAND). AMERICAN JOURNAL OF MEDICAL GENETICS. PART C, SEMINARS IN MEDICAL GENETICS, 178(3), 309-320 [10.1002/ajmg.c.31637].
de Vries, Pj; Wilde, L; de Vries, Mc; Moavero, R; Pearson, Da; Curatolo, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/212764
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