Purpose F-18-DOPA PET/CT is potentially helpful in the management of patients with low-grade brain tumors, movement disorders, and somatic neuroendocrine tumors. We describe the whole-body physiological distribution of F-18-DOPA uptake.Patients and Methods We examined 215 patients with F-18-DOPA PET/CT. Among these, 161 had brain scans and 54 had whole-body scans.Results Physiological distribution was negligible in the brain, with the exception of basal ganglia, whereas greatest activity was noted in the liver, pancreas, other exocrine glands, and the urinary system. Incidental tracer uptake sites were identified in 5.5% of patients. Some of these findings were due to inflammation, whereas in most cases, uptake was seen in benign tumors of the brain or in the endocrine or exocrine glands.Conclusions F-18-DOPA uptake may be seen in inflammatory tissue or benign tumors. Correlations with history, physical examination, laboratory examination, CT, MRI, and histology are necessary for optimal diagnosis.

Calabria, F.f., Chiaravalloti, A., Jaffrain-Rea, M.l., Zinzi, M., Sannino, P., Minniti, G., et al. (2016). 18F-dopa pet/ct physiological distribution and pitfalls: Experience in 215 patients. CLINICAL NUCLEAR MEDICINE, 41(10), 753-760 [10.1097/RLU.0000000000001318].

18F-dopa pet/ct physiological distribution and pitfalls: Experience in 215 patients

Chiaravalloti A.;Schillaci O.
2016-01-01

Abstract

Purpose F-18-DOPA PET/CT is potentially helpful in the management of patients with low-grade brain tumors, movement disorders, and somatic neuroendocrine tumors. We describe the whole-body physiological distribution of F-18-DOPA uptake.Patients and Methods We examined 215 patients with F-18-DOPA PET/CT. Among these, 161 had brain scans and 54 had whole-body scans.Results Physiological distribution was negligible in the brain, with the exception of basal ganglia, whereas greatest activity was noted in the liver, pancreas, other exocrine glands, and the urinary system. Incidental tracer uptake sites were identified in 5.5% of patients. Some of these findings were due to inflammation, whereas in most cases, uptake was seen in benign tumors of the brain or in the endocrine or exocrine glands.Conclusions F-18-DOPA uptake may be seen in inflammatory tissue or benign tumors. Correlations with history, physical examination, laboratory examination, CT, MRI, and histology are necessary for optimal diagnosis.
2016
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA
English
Con Impact Factor ISI
PET/CT; F-18-DOPA; brain tumor; pitfalls; molecular imaging; Adult; Aged; Biological Transport; Brain Neoplasms; Dihydroxyphenylalanine; Female; Humans; Male; Middle Aged; Whole Body Imaging; Young Adult; Fluorine Radioisotopes; Positron Emission Tomography Computed Tomography
https://ovidsp.tx.ovid.com/sp-3.33.0b/ovidweb.cgi?QS2=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
Calabria, F.f., Chiaravalloti, A., Jaffrain-Rea, M.l., Zinzi, M., Sannino, P., Minniti, G., et al. (2016). 18F-dopa pet/ct physiological distribution and pitfalls: Experience in 215 patients. CLINICAL NUCLEAR MEDICINE, 41(10), 753-760 [10.1097/RLU.0000000000001318].
Calabria, Ff; Chiaravalloti, A; Jaffrain-Rea, Ml; Zinzi, M; Sannino, P; Minniti, G; Rubello, D; Schillaci, O
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/212699
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