To assess the prognostic role of total lesion glycolysis (TLG) in patients with breast cancer liver metastases (BCLM) after sequential lobar Y-90-radioembolization (Y-90-RE). Seventeen patients with bilobar BCLM underwent FDG PET/CT and TLG calculation before Y-90-RE. The hepatic lobe with the highest TLG was treated in the first session. PET was performed 6 weeks postprocedure and decrease in TLG (TLG) in the treated lobe was calculated before the second Y-90 administration. Subjects were divided in two groups (group 1: TLG >50%, group 2: TLG <50%). After the two consecutive Y-90-therapies, patients underwent follow-up until death. Statistical analysis was performed to identify prognostic factors on overall survival (OS). After the first Y-90 administration, 10 cases showed a TLG >50% and seven had a TLG value <50%. After the two consecutive procedures, the mean OS for all patients was 13.5 +/- 0.8 months. Subjects with a TLG >50% and TLG <50% had a mean OS of 16.4 +/- 0.6 and 10.3 +/- 0.4 months, respectively (p<0.001). Cox regression analysis demonstrated hepatic tumor load (p=0.048) and TLG as the only significant (p=0.005) predictors of survival. TLG after the first Y-90 administration agrees with final outcome in BCLM patients after separate sequential lobar Y-90-RE.

Bagni, O., Filippi, L., Pelle, G., Cianni, R., Schillaci, O. (2015). Total Lesion Glycolysis and Sequential90Y-Selective Internal Radiation Therapy in Breast Cancer Liver Metastases: Preliminary Results. CANCER BIOTHERAPY & RADIOPHARMACEUTICALS, 30(10), 421-426 [10.1089/cbr.2015.1877].

Total Lesion Glycolysis and Sequential90Y-Selective Internal Radiation Therapy in Breast Cancer Liver Metastases: Preliminary Results

Filippi L.;Schillaci O.
2015-01-01

Abstract

To assess the prognostic role of total lesion glycolysis (TLG) in patients with breast cancer liver metastases (BCLM) after sequential lobar Y-90-radioembolization (Y-90-RE). Seventeen patients with bilobar BCLM underwent FDG PET/CT and TLG calculation before Y-90-RE. The hepatic lobe with the highest TLG was treated in the first session. PET was performed 6 weeks postprocedure and decrease in TLG (TLG) in the treated lobe was calculated before the second Y-90 administration. Subjects were divided in two groups (group 1: TLG >50%, group 2: TLG <50%). After the two consecutive Y-90-therapies, patients underwent follow-up until death. Statistical analysis was performed to identify prognostic factors on overall survival (OS). After the first Y-90 administration, 10 cases showed a TLG >50% and seven had a TLG value <50%. After the two consecutive procedures, the mean OS for all patients was 13.5 +/- 0.8 months. Subjects with a TLG >50% and TLG <50% had a mean OS of 16.4 +/- 0.6 and 10.3 +/- 0.4 months, respectively (p<0.001). Cox regression analysis demonstrated hepatic tumor load (p=0.048) and TLG as the only significant (p=0.005) predictors of survival. TLG after the first Y-90 administration agrees with final outcome in BCLM patients after separate sequential lobar Y-90-RE.
2015
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA
English
Con Impact Factor ISI
90Y-radioembolization; FDG-PET; breast cancer; liver metastases; total lesion glycolysis; Adult; Aged; Biomarkers, Tumor; Breast Neoplasms; Female; Fluorodeoxyglucose F18; Follow-Up Studies; Humans; Liver Neoplasms; Middle Aged; Positron-Emission Tomography; Survival Rate; Tomography, X-Ray Computed; Tumor Burden; Yttrium Radioisotopes; Embolization, Therapeutic; Glycolysis
https://www.liebertpub.com/doi/10.1089/cbr.2015.1877
Bagni, O., Filippi, L., Pelle, G., Cianni, R., Schillaci, O. (2015). Total Lesion Glycolysis and Sequential90Y-Selective Internal Radiation Therapy in Breast Cancer Liver Metastases: Preliminary Results. CANCER BIOTHERAPY & RADIOPHARMACEUTICALS, 30(10), 421-426 [10.1089/cbr.2015.1877].
Bagni, O; Filippi, L; Pelle, G; Cianni, R; Schillaci, O
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/212679
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