Intrahepatic cholangiocarcinoma (ICC) is a severe and rapidly progressive hepatic tumor. Surgery is often impracticable due to locally advanced presentation. On the other hand, chemotherapy has demonstrated only limited effectiveness. For these reasons, liver-directed therapies have been successfully applied for treating ICC. In particular, radioembolization with Yttrium-90 (Y-90)-labeled spheres has been reported to be a promising therapeutic approach for this neoplasia. Two commercial forms of Y-90-labeled spheres are available: glass (TheraSphere (R)) and resin (SIR-Spheres (R)) microspheres. The aim of the present paper is to review the existing literature on the use of the resin microspheres for the treatment of unresectable and chemorefractory ICC, focusing on the methodology, clinical applications and side effects.

Filippi, L., Schillaci, O., Cianni, R., Bagni, O. (2017). Yttrium-90 resin microspheres and their use in the treatment of intrahepatic cholangiocarcinoma. FUTURE ONCOLOGY, 14(9), 809-818 [10.2217/fon-2017-0443].

Yttrium-90 resin microspheres and their use in the treatment of intrahepatic cholangiocarcinoma

Filippi L.;Schillaci O.;
2017-12-01

Abstract

Intrahepatic cholangiocarcinoma (ICC) is a severe and rapidly progressive hepatic tumor. Surgery is often impracticable due to locally advanced presentation. On the other hand, chemotherapy has demonstrated only limited effectiveness. For these reasons, liver-directed therapies have been successfully applied for treating ICC. In particular, radioembolization with Yttrium-90 (Y-90)-labeled spheres has been reported to be a promising therapeutic approach for this neoplasia. Two commercial forms of Y-90-labeled spheres are available: glass (TheraSphere (R)) and resin (SIR-Spheres (R)) microspheres. The aim of the present paper is to review the existing literature on the use of the resin microspheres for the treatment of unresectable and chemorefractory ICC, focusing on the methodology, clinical applications and side effects.
dic-2017
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA
English
Con Impact Factor ISI
SIR-spheres; dosimetry; imaging; intrahepatic cholangiocarcinoma; radioembolization; therapy; Cholangiocarcinoma; Embolization, Therapeutic; Humans; Liver Neoplasms; Microspheres; Radiopharmaceuticals; Treatment Outcome; Yttrium Radioisotopes
https://www.futuremedicine.com/doi/10.2217/fon-2017-0443
Filippi, L., Schillaci, O., Cianni, R., Bagni, O. (2017). Yttrium-90 resin microspheres and their use in the treatment of intrahepatic cholangiocarcinoma. FUTURE ONCOLOGY, 14(9), 809-818 [10.2217/fon-2017-0443].
Filippi, L; Schillaci, O; Cianni, R; Bagni, O
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/212645
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