Background The aim of this study was to investigate the relationship between age and uptake of fluorine-18-L-dihydroxyphenylalanine (18F-DOPA) in the brain and myocardial uptake of iodine-123-metaiodobenzylguanidine (123I-MIBG) in normal adult participants. Participants and methods To this end, a total of 72 healthy participants were enroled. Of these, 37 individuals (male, 21; female, 16; mean age: 60±12 years; age range: 38–85 years) underwent 18F-DOPA PET/CT, whereas 35 individuals (male, 19; female, 16; mean age: 61±17 years; age range: 17–87 years) underwent 123I-MIBG scintigraphy. For 18F-DOPA PET/CT, regions of interest were placed on the caudate nucleus, globus pallidus and putamen by means of the WFU Pickatlas tool implemented in SPM8 and further analysed after a normalization process. For 123I-MIBG scintigraphy, regions of interest were set over the upper mediastinum and a heart-to-mediastinum count ratio was calculated. The relation between age and normalized 18F-DOPA values or heart-to-mediastinum ratio values was examined using correlation analysis of variance and Pearson’s correlation coefficient. Results We did not find any significant relationship between age and 18F-DOPA and 123I-MIBG uptake, respectively. Conclusion Our findings suggest that both brain 18F-DOPA PET/CT and cardiac 123I-MIBG scintigraphy represent age-independent biomarkers whose analyses of quantitative uptake may not require adjustment for patients’ age.
Chiaravalloti, A., Barbagallo, G., Ricci, M., Sannino, P., Karalis, G., Ursini, F., et al. (2018). Ageing effect on 18 F-DOPA and 123 I-MIBG uptake: A cross-sectional study. NUCLEAR MEDICINE COMMUNICATIONS, 39(6), 539-544 [10.1097/MNM.0000000000000835].
|Tipologia:||Articolo su rivista|
|Citazione:||Chiaravalloti, A., Barbagallo, G., Ricci, M., Sannino, P., Karalis, G., Ursini, F., et al. (2018). Ageing effect on 18 F-DOPA and 123 I-MIBG uptake: A cross-sectional study. NUCLEAR MEDICINE COMMUNICATIONS, 39(6), 539-544 [10.1097/MNM.0000000000000835].|
|IF:||Con Impact Factor ISI|
|Settore Scientifico Disciplinare:||Settore MED/36 - Diagnostica per Immagini e Radioterapia|
|Revisione (peer review):||Esperti anonimi|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1097/MNM.0000000000000835|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||2018|
|Titolo:||Ageing effect on 18 F-DOPA and 123 I-MIBG uptake: A cross-sectional study|
|Autori:||Chiaravalloti, A; Barbagallo, G; Ricci, M; Sannino, P; Karalis, G; Ursini, F; Schillaci, O|
|Appare nelle tipologie:||01 - Articolo su rivista|