ATM kinase is a gatekeeper of genome stability. However, its role in several other signaling pathways suggests that it might not always act as a tumor suppressor. Here, we discuss recent data that unveil a function of ATM as a tumor promoter in HER2-positive breast cancer.
Stagni, V., Oropallo, V., Barila, D. (2016). ATM: An unexpected tumor-promoting factor in HER2-expressing tumors. MOLECULAR & CELLULAR ONCOLOGY, 3(2), e1054551 [10.1080/23723556.2015.1054551].
ATM: An unexpected tumor-promoting factor in HER2-expressing tumors
OROPALLO, VERONICA;Barila D.
2016-03-01
Abstract
ATM kinase is a gatekeeper of genome stability. However, its role in several other signaling pathways suggests that it might not always act as a tumor suppressor. Here, we discuss recent data that unveil a function of ATM as a tumor promoter in HER2-positive breast cancer.File in questo prodotto:
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