Thymosin alpha 1 (Tα1) is a well-recognized immune response modulator in a wide range of disorders, particularly infections and cancer. The bioinformatic analysis of public databases allows drug repositioning, predicting a new potential area of clinical intervention. We aimed to decipher the cellular network induced by Tα1 treatment to confirm present use and identify new potential clinical applications.

Matteucci, C., Argaw-Denboba, A., Balestrieri, E., Giovinazzo, A., Miele, M., D'Agostini, C., et al. (2018). Deciphering cellular biological processes to clinical application: a new perspective for Tα1 treatment targeting multiple diseases. EXPERT OPINION ON BIOLOGICAL THERAPY, 18(sup1), 23-31 [10.1080/14712598.2018.1474198].

Deciphering cellular biological processes to clinical application: a new perspective for Tα1 treatment targeting multiple diseases

Matteucci C.;Balestrieri E.;Giovinazzo A.;D'Agostini C.;Pica F.;Grelli S.;Paci M.;Sinibaldi Vallebona P.;Garaci E.;
2018-07-01

Abstract

Thymosin alpha 1 (Tα1) is a well-recognized immune response modulator in a wide range of disorders, particularly infections and cancer. The bioinformatic analysis of public databases allows drug repositioning, predicting a new potential area of clinical intervention. We aimed to decipher the cellular network induced by Tα1 treatment to confirm present use and identify new potential clinical applications.
lug-2018
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
English
Cancer
chronic disease
drug repositioning
drug target discovery
enrichment analysis
infectious diseases
thymosin alpha
Autoimmune Diseases
Biological Phenomena
Gene Expression Profiling
Gene Regulatory Networks
Humans
Infections
Leukocytes, Mononuclear
Microarray Analysis
Neoplasms
Signal Transduction
Thymalfasin
Transcriptome
Cancer; chronic disease; drug repositioning; drug target discovery; enrichment analysis; infectious diseases; thymosin alpha; Autoimmune Diseases; Biological Phenomena; Gene Expression Profiling; Gene Regulatory Networks; Humans; Infection; Leukocytes, Mononuclear; Microarray Analysis; Neoplasms; Signal Transduction; Thymalfasin; Transcriptome
Matteucci, C., Argaw-Denboba, A., Balestrieri, E., Giovinazzo, A., Miele, M., D'Agostini, C., et al. (2018). Deciphering cellular biological processes to clinical application: a new perspective for Tα1 treatment targeting multiple diseases. EXPERT OPINION ON BIOLOGICAL THERAPY, 18(sup1), 23-31 [10.1080/14712598.2018.1474198].
Matteucci, C; Argaw-Denboba, A; Balestrieri, E; Giovinazzo, A; Miele, M; D'Agostini, C; Pica, F; Grelli, S; Paci, M; Mastino, A; Sinibaldi Vallebona, ...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/211489
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