The autoxidation of 4-methylcatechol under quasi-physiological conditions, leading to 2-hydroxy-5-methyl-1,4-benzoquinone, was investigated. The effects of pH and metal ions were examined. An electrophilic attack of dioxygen to the 4-methylcatechol monoanion to form a transient peroxo species is proposed. It was concluded that such a non-enzymic conversion is likely for this model compound and for its physiological counterpart, a specific tyrosyl residue incorporated in the protein chain at the active site of copper amine oxidases.
Rinaldi, A., Porcu, M., Curreli, N., Rescigno, A., Finazzi-Agró, A., Pedersen, J., et al. (1995). Autoxidation of 4-methylcatechol: a model for the study of the biosynthesis of copper amine oxidases quinonoid cofactor. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 214(2), 559-567.
Tipologia: | Articolo su rivista |
Citazione: | Rinaldi, A., Porcu, M., Curreli, N., Rescigno, A., Finazzi-Agró, A., Pedersen, J., et al. (1995). Autoxidation of 4-methylcatechol: a model for the study of the biosynthesis of copper amine oxidases quinonoid cofactor. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 214(2), 559-567. |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore BIO/10 |
Revisione (peer review): | Esperti anonimi |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | 14-set-1995 |
Titolo: | Autoxidation of 4-methylcatechol: a model for the study of the biosynthesis of copper amine oxidases quinonoid cofactor |
Autori: | |
Autori: | Rinaldi, A; Porcu, M; Curreli, N; Rescigno, A; Finazzi-Agró, A; Pedersen, J; Rinaldi, A; Sanjust, E |
Appare nelle tipologie: | 01 - Articolo su rivista |