The antioxidant properties of the antithrombotic drug dipyridamole have been studied using lipid oxidation assays based on the generation of peroxy radicals by azo compounds. Dipyridamole was observed to prevent both peroxidation of arachidonic acid micelles in aqueous solution and peroxidation of methyl linoleate in organic solvents; in contrast to vitamin E, dipyridamole was found to scavenge both hydrophilic and hydrophobic radicals. The rate constant for the reaction of dipyridamole with methyl linoleate peroxyl radicals at 37 degrees C was calculated as 2 x 10(6) M-1s-1, in comparison to 1 x 10(6) M-1s-1 of vitamin E under the same conditions. The antioxidant efficiency of the drug was confirmed in experiments with radiolysis-induced oxidation and through measurements of malondialdehyde production and diene formation. As a result of radical scavenging, a relatively stable dipyridamole radical was formed that could be detected by electron spin resonance spectroscopy. The particular antioxidant properties of dipyridamole may explain the vasodilating and antiplatelet effects of this cardiovascular drug.

Iuliano, L., Pedersen, J., Rotilio, G., Ferro, D., Violi, F. (1995). A potent chain-breaking antioxidant activity of the cardiovascular drug dipyridamole. FREE RADICAL BIOLOGY & MEDICINE, 18(2), 239-247.

A potent chain-breaking antioxidant activity of the cardiovascular drug dipyridamole

Pedersen JZ;Rotilio G;
1995-02-01

Abstract

The antioxidant properties of the antithrombotic drug dipyridamole have been studied using lipid oxidation assays based on the generation of peroxy radicals by azo compounds. Dipyridamole was observed to prevent both peroxidation of arachidonic acid micelles in aqueous solution and peroxidation of methyl linoleate in organic solvents; in contrast to vitamin E, dipyridamole was found to scavenge both hydrophilic and hydrophobic radicals. The rate constant for the reaction of dipyridamole with methyl linoleate peroxyl radicals at 37 degrees C was calculated as 2 x 10(6) M-1s-1, in comparison to 1 x 10(6) M-1s-1 of vitamin E under the same conditions. The antioxidant efficiency of the drug was confirmed in experiments with radiolysis-induced oxidation and through measurements of malondialdehyde production and diene formation. As a result of radical scavenging, a relatively stable dipyridamole radical was formed that could be detected by electron spin resonance spectroscopy. The particular antioxidant properties of dipyridamole may explain the vasodilating and antiplatelet effects of this cardiovascular drug.
feb-1995
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/10 - BIOCHIMICA
English
Antioxidants; Arachidonic Acid; Dipyridamole; Free Radicals; Kinetics; Linoleic Acids; Lipid Peroxidation; Malondialdehyde; Micelles; Peroxides; Solvents; Vitamin E
Iuliano, L., Pedersen, J., Rotilio, G., Ferro, D., Violi, F. (1995). A potent chain-breaking antioxidant activity of the cardiovascular drug dipyridamole. FREE RADICAL BIOLOGY & MEDICINE, 18(2), 239-247.
Iuliano, L; Pedersen, J; Rotilio, G; Ferro, D; Violi, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/210830
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